Research Article

Co-inheritance of variants/mutations in Malaysian patients with Crohn’s disease

Published: August 31, 2012
Genet. Mol. Res. 11 (3) : 3115-3121 DOI: https://doi.org/10.4238/2012.August.31.9
Cite this Article:
(2012). Co-inheritance of variants/mutations in Malaysian patients with Crohn’s disease. Genet. Mol. Res. 11(3): gmr2041. https://doi.org/10.4238/2012.August.31.9
1,139 views

Abstract

Crohn’s disease is a chronic, relapsing inflammatory bowel disease; it affects the mucosa and deeper layers of the digestive wall. Two Crohn’s disease patients who carried the JW1 variant and two patients who carried the SNP5 variant were investigated for other co-inherited polymorphisms that could influence Crohn’s disease development. Based on the sequencing results, a homozygous 5ꞌ-UTR-59 G to A variant in exon 1 (SNP6) was observed in a patient who carried SNP5, while a heterozygous SNP6 variant was detected in the other patient who carried SNP5. No other associated mutations or polymorphisms were detected in the two patients who carried the JW1 variant of the CARD15/NOD2 gene.

Crohn’s disease is a chronic, relapsing inflammatory bowel disease; it affects the mucosa and deeper layers of the digestive wall. Two Crohn’s disease patients who carried the JW1 variant and two patients who carried the SNP5 variant were investigated for other co-inherited polymorphisms that could influence Crohn’s disease development. Based on the sequencing results, a homozygous 5ꞌ-UTR-59 G to A variant in exon 1 (SNP6) was observed in a patient who carried SNP5, while a heterozygous SNP6 variant was detected in the other patient who carried SNP5. No other associated mutations or polymorphisms were detected in the two patients who carried the JW1 variant of the CARD15/NOD2 gene.

About the Authors