Research Article

Cytogenetic and molecular analysis of infertile Chinese men: karyotypic abnormalities, Y-chromosome microdeletions, and CAG and GGN repeat polymorphisms in the androgen receptor gene

Published: July 08, 2013
Genet. Mol. Res. 12 (3) : 2215-2226 DOI: https://doi.org/10.4238/2013.July.8.3
Cite this Article:
T.T. Han, J. Ran, X.P. Ding, L.J. Li, L.Y. Zhang, Y.P. Zhang, S.S. Nie, L. Chen (2013). Cytogenetic and molecular analysis of infertile Chinese men: karyotypic abnormalities, Y-chromosome microdeletions, and CAG and GGN repeat polymorphisms in the androgen receptor gene. Genet. Mol. Res. 12(3): 2215-2226. https://doi.org/10.4238/2013.July.8.3
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Abstract

Chromosome abnormalities, Y-chromosome microde­letions, and androgen receptor gene CAG and GGN repeat polymor­phisms in infertile Chinese men featuring severe oligospermia and azoospermia were analyzed. Ninety-six fertile men and 189 non-ob­structive infertile men, including 125 patients with azoospermia and 64 with severe oligozoospermia, were studied. Seventeen infertile men (9.0%) carried a chromosome abnormality. Twenty (10.6%) carried a Y-chromosome microdeletion. In the remainder of the patients and con­trols, GGN and CAG repeats were sequenced. Short GGN repeats (n 2.5-fold risk (OR = 2.539, 95%CI = 1.206-5.344, P

Chromosome abnormalities, Y-chromosome microde­letions, and androgen receptor gene CAG and GGN repeat polymor­phisms in infertile Chinese men featuring severe oligospermia and azoospermia were analyzed. Ninety-six fertile men and 189 non-ob­structive infertile men, including 125 patients with azoospermia and 64 with severe oligozoospermia, were studied. Seventeen infertile men (9.0%) carried a chromosome abnormality. Twenty (10.6%) carried a Y-chromosome microdeletion. In the remainder of the patients and con­trols, GGN and CAG repeats were sequenced. Short GGN repeats (n 2.5-fold risk (OR = 2.539, 95%CI = 1.206-5.344, P