Research Article

Olfactory mucosal microstructural changes in a rat model of acute rhinosinusitis with dysosmia

Published: May 16, 2014
Genet. Mol. Res. 13 (2) : 3859-3868 DOI: https://doi.org/10.4238/2014.May.16.11
Cite this Article:
(2014). Olfactory mucosal microstructural changes in a rat model of acute rhinosinusitis with dysosmia. Genet. Mol. Res. 13(2): gmr3895. https://doi.org/10.4238/2014.May.16.11
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Abstract

This study aimed to examine olfactory mucosal changes in a rat model of acute rhinosinusitis and to determine how acute rhinosinusitis induces dysosmia. Total 100 rats were divided into the experimental (N = 80) and control (N = 20) groups. An acute rhinosinusitis model was established in the experimental rats. From the experimental group, 20 rats each were sacrificed at 1, 2, 3, or 4 weeks. The control group was sacrificed at 1 week without inoculation. Olfaction was tested by the buried food pellet test before killing the rats, and the duration until the pellet was recorded and analyzed by a statistical software program. Mature olfactory receptor neurons (ORNs) and olfactory ensheathing cells (OECs) were examined. The durations spent by the experimental group in the BFPT were 402.9 ± 9.3, 453.7 ± 7.3, 351.9 ± 8.9, and 278.7 ± 8.1 s at 1, 2, 3, and 4 weeks, respectively. These durations were greater than that of the control group (178.3 ± 6.6 s), and the difference was statistically significant (P

This study aimed to examine olfactory mucosal changes in a rat model of acute rhinosinusitis and to determine how acute rhinosinusitis induces dysosmia. Total 100 rats were divided into the experimental (N = 80) and control (N = 20) groups. An acute rhinosinusitis model was established in the experimental rats. From the experimental group, 20 rats each were sacrificed at 1, 2, 3, or 4 weeks. The control group was sacrificed at 1 week without inoculation. Olfaction was tested by the buried food pellet test before killing the rats, and the duration until the pellet was recorded and analyzed by a statistical software program. Mature olfactory receptor neurons (ORNs) and olfactory ensheathing cells (OECs) were examined. The durations spent by the experimental group in the BFPT were 402.9 ± 9.3, 453.7 ± 7.3, 351.9 ± 8.9, and 278.7 ± 8.1 s at 1, 2, 3, and 4 weeks, respectively. These durations were greater than that of the control group (178.3 ± 6.6 s), and the difference was statistically significant (P

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