Research Article

Pulmonary hypertension in patients with stage 1-3 chronic kidney disease

Published: July 25, 2014
Genet. Mol. Res. 13 (3) : 5695-5703 DOI: https://doi.org/10.4238/2014.July.25.25
Cite this Article:
(2014). Pulmonary hypertension in patients with stage 1-3 chronic kidney disease. Genet. Mol. Res. 13(3): gmr4564. https://doi.org/10.4238/2014.July.25.25
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Abstract

Pulmonary hypertension (PH) secondary to chronic kidney disease (CKD) is common, but in stages 1-3 CKD patients, it remains unclear. We sought to evaluate the prevalence of PH and elucidate the possible pathogenesis in Chinese patients with early stage kidney disease. Doppler-estimated pulmonary systolic artery pressure (PASP) was measured in 101 CKD patients with glomerular filtration rate (GFR) ≥60 mL/min/1.73 m2 and 27 CKD patients with GFR 2. Echocardiographic parameters, plasma brain natriuretic peptide (BNP), and baseline characteristics of patients were recorded. PH was defined as a PASP ≥ 35 mmHg. PH prevalence was 23.76% (24/101) in GFR ≥ 60 mL/min/1.73 m2 group and 48.15% (13/27) in GFR 2 group, P 2) compared to non-PH group (75.59 ± 31.62 mL/min/1.73 m2), P

Pulmonary hypertension (PH) secondary to chronic kidney disease (CKD) is common, but in stages 1-3 CKD patients, it remains unclear. We sought to evaluate the prevalence of PH and elucidate the possible pathogenesis in Chinese patients with early stage kidney disease. Doppler-estimated pulmonary systolic artery pressure (PASP) was measured in 101 CKD patients with glomerular filtration rate (GFR) ≥60 mL/min/1.73 m2 and 27 CKD patients with GFR 2. Echocardiographic parameters, plasma brain natriuretic peptide (BNP), and baseline characteristics of patients were recorded. PH was defined as a PASP ≥ 35 mmHg. PH prevalence was 23.76% (24/101) in GFR ≥ 60 mL/min/1.73 m2 group and 48.15% (13/27) in GFR 2 group, P 2) compared to non-PH group (75.59 ± 31.62 mL/min/1.73 m2), P

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