Research Article

KCNE1 112G>A polymorphism and atrial fibrillation risk: a meta-analysis

Published: October 20, 2014
Genet. Mol. Res. 13 (4) : 8367-8377 DOI: https://doi.org/10.4238/2014.October.20.12
Cite this Article:
(2014). KCNE1 112G>A polymorphism and atrial fibrillation risk: a meta-analysis. Genet. Mol. Res. 13(4): gmr3885. https://doi.org/10.4238/2014.October.20.12
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Abstract

KCNE1, a membrane protein that spans the membrane once is responsible for modulating potassium channel functions and plays an important role in the etiology of arrhythmia. Emerging evidence indicates that a common polymorphism (112G>A; rs1805127 G>A) in the KCNE1 gene contributes to atrial fibrillation (AF) risk; however, these studies showed inconclusive results. In this meta-analysis, we derived a more precise estimation of the association between the KCNE1 112G>A polymorphism and AF risk. The following databases were searched: Web of Science (1945-2013), the Cochrane Library Database (Issue 12, 2013), PubMed (1966-2013), EMBASE (1980-2013), CINAHL (1982-2013), and the Chinese Biomedical Database (1982-2013). The crude odds ratios with their 95% confidence intervals were calculated. Nine case-control studies were included, with a total of 1792 AF patients and 1924 healthy controls. The meta-analysis results indicated that the KCNE1 112G variant is associated with an increased risk of AF. Further subgroup analysis based on ethnicity revealed significant associations between the KCNE1 112G variant and an increased risk of AF among both Asians and Caucasians. No publication bias was detected in this meta-analysis. In conclusion, our results indicate that the KCNE1 112G polymorphism may be a risk factor for AF. KCNE1 112G>A may be useful as a biomarker for predicting the development of AF.

KCNE1, a membrane protein that spans the membrane once is responsible for modulating potassium channel functions and plays an important role in the etiology of arrhythmia. Emerging evidence indicates that a common polymorphism (112G>A; rs1805127 G>A) in the KCNE1 gene contributes to atrial fibrillation (AF) risk; however, these studies showed inconclusive results. In this meta-analysis, we derived a more precise estimation of the association between the KCNE1 112G>A polymorphism and AF risk. The following databases were searched: Web of Science (1945-2013), the Cochrane Library Database (Issue 12, 2013), PubMed (1966-2013), EMBASE (1980-2013), CINAHL (1982-2013), and the Chinese Biomedical Database (1982-2013). The crude odds ratios with their 95% confidence intervals were calculated. Nine case-control studies were included, with a total of 1792 AF patients and 1924 healthy controls. The meta-analysis results indicated that the KCNE1 112G variant is associated with an increased risk of AF. Further subgroup analysis based on ethnicity revealed significant associations between the KCNE1 112G variant and an increased risk of AF among both Asians and Caucasians. No publication bias was detected in this meta-analysis. In conclusion, our results indicate that the KCNE1 112G polymorphism may be a risk factor for AF. KCNE1 112G>A may be useful as a biomarker for predicting the development of AF.