Research Article

Etiological factors, prognostic assessment, and outcomes of patients with acute kidney injury and multiple organ dysfunction syndrome

Published: October 20, 2014
Genet. Mol. Res. 13 (4) : 8378-8384 DOI: https://doi.org/10.4238/2014.October.20.13
Cite this Article:
Z. Gao, D.W. Mu, L. Guo, X.M. Li, L.D. Lun (2014). Etiological factors, prognostic assessment, and outcomes of patients with acute kidney injury and multiple organ dysfunction syndrome. Genet. Mol. Res. 13(4): 8378-8384. https://doi.org/10.4238/2014.October.20.13
1,649 views

Abstract

This clinical study assessed the etiological factors implicated in acute kidney injury (AKI). AKI has a complicated etiology with many serious complications. Understanding the interactions among these factors will help physicians treat patients with AKI. This retrospective study analyzed the etiological factors and assessed the incidence and outcome of 123 patients with AKI and multiple organ dysfunction syndrome. The general conditions, original disease, number of organ dysfunctions, type of organ dysfunction, complications, score, time, dose of renal replacement therapy, and outcomes were recorded. The etiologies of the manifested diseases were complicated. The number of injured organs was directly associated with prognosis. Cardiovascular dysfunction and cataphora were independently associated with a risk of mortality (P < 0.05; odds ratios: 12.44 and 2.16, respectively). Meanwhile, cardiovascular dysfunction and choloplania were independently associated with a risk of irreparable renal function (P < 0.05; odds ratios: 23.64 and 11.59, respectively). In summary, the etiologies of the manifested diseases are complex. In addition, cardiovascular dysfunction is significantly associated with prognosis including survival and the recovery rate of renal function.

This clinical study assessed the etiological factors implicated in acute kidney injury (AKI). AKI has a complicated etiology with many serious complications. Understanding the interactions among these factors will help physicians treat patients with AKI. This retrospective study analyzed the etiological factors and assessed the incidence and outcome of 123 patients with AKI and multiple organ dysfunction syndrome. The general conditions, original disease, number of organ dysfunctions, type of organ dysfunction, complications, score, time, dose of renal replacement therapy, and outcomes were recorded. The etiologies of the manifested diseases were complicated. The number of injured organs was directly associated with prognosis. Cardiovascular dysfunction and cataphora were independently associated with a risk of mortality (P

About the Authors