Research Article

Differential gene expression of epigenetic modifying enzymes between Tibet pig and Yorkshire in high and low altitudes

Published: April 13, 2015
Genet. Mol. Res. 14 (2) : 3274-3280 DOI: 10.4238/2015.April.13.6

Abstract

Epigenetic modifying enzymes play important roles in the adaptation to hypoxia, although no studies have examined their expression levels in Tibet pigs. The lung is an important functional organ in hypoxia adaptation. In this study, we examined the mRNA expression level of 5 enzymes in the lung of Tibet pigs using real-time polymerase chain reaction to determine the epigenetic performance of hypoxia adaptation. We selected four groups of pig as the study object, which were Tibet pig in highland (TH), Yorkshire in highland (YH), Tibet pig in lowland (TL), Yorkshire in lowland (YL). Expression of Dnmt1 in Tibet pig was higher than that in Yorkshire (P Dnmt3a was higher in Tibet pig than that in Yorkshire (P Hdac1 was higher in group TH than in Yorkshire (P Kdm3a was higher in group TH than in the rest of the groups (P Uhrf1 was higher in Tibet pig than in Yorkshire (P

Epigenetic modifying enzymes play important roles in the adaptation to hypoxia, although no studies have examined their expression levels in Tibet pigs. The lung is an important functional organ in hypoxia adaptation. In this study, we examined the mRNA expression level of 5 enzymes in the lung of Tibet pigs using real-time polymerase chain reaction to determine the epigenetic performance of hypoxia adaptation. We selected four groups of pig as the study object, which were Tibet pig in highland (TH), Yorkshire in highland (YH), Tibet pig in lowland (TL), Yorkshire in lowland (YL). Expression of Dnmt1 in Tibet pig was higher than that in Yorkshire (P Dnmt3a was higher in Tibet pig than that in Yorkshire (P Hdac1 was higher in group TH than in Yorkshire (P Kdm3a was higher in group TH than in the rest of the groups (P Uhrf1 was higher in Tibet pig than in Yorkshire (P