Research Article

β-asarone from Acorus gramineus alleviates depression by modulating MKP-1

Published: May 04, 2015
Genet. Mol. Res. 14 (2) : 4495-4504 DOI: https://doi.org/10.4238/2015.May.4.7
Cite this Article:
Y.R. Sun, X.Y. Wang, S.S. Li, H.Y. Dong, X.J. Zhang (2015). β-asarone from Acorus gramineus alleviates depression by modulating MKP-1. Genet. Mol. Res. 14(2): 4495-4504. https://doi.org/10.4238/2015.May.4.7
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Abstract

In this study, we investigated the antidepressant effects of hippocampal neuron administration of β-asarone, a selective mitogen-activated protein kinase phosphatase-1 inhibitor, in a rat model of depression. Our previous studies showed that the extracellular signal-regulated kinase signaling pathway and brain-derived neurotrophic factor expression, which is regulated by extracellular signal-regulated kinase, are key links in the biological mechanism of depression. Mitogen-activated protein kinase phosphatase-1 (MKP-1) is a negative regulatory protein of extracellular signal-regulated kinase signaling pathways. In this study, we explored the regulation of MKP-1 by β-asarone in producing an antidepressant effect.

In this study, we investigated the antidepressant effects of hippocampal neuron administration of β-asarone, a selective mitogen-activated protein kinase phosphatase-1 inhibitor, in a rat model of depression. Our previous studies showed that the extracellular signal-regulated kinase signaling pathway and brain-derived neurotrophic factor expression, which is regulated by extracellular signal-regulated kinase, are key links in the biological mechanism of depression. Mitogen-activated protein kinase phosphatase-1 (MKP-1) is a negative regulatory protein of extracellular signal-regulated kinase signaling pathways. In this study, we explored the regulation of MKP-1 by β-asarone in producing an antidepressant effect.