Research Article

Disease indicators for sepsis and analysis of sepsis treatment in children using the continuous blood purification technique

Published: May 25, 2015
Genet. Mol. Res. 14 (2) : 5685-5693 DOI: 10.4238/2015.May.25.21

Abstract

We analyzed disease severity, inflammation markers, and dynamic changes in cartilage glycoprotein 39 (YKL-40) and C-reactive protein (CRP) levels in children with sepsis before and after treatment with continuous blood purification (CBP). Study participants were 30 children with severe sepsis who were cured from the disease (experimental group) in the Children’s Serious Disease Center of In­ner Mongolia People’s Hospital between June 2012 and October 2013. Symptomatic CBP treatment was performed after disease severity scor­ing. Interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), YKL-40, and CRP levels were tested 0, 12, 24, and 48 h after CBP treatment. YKL-40 mRNA expression in whole blood was determined biochemi­cally, and its expression in peripheral blood was determined with an immunochemical method. We found a significant difference in disease severity scores before and 48 h after CBP treatment (P

We analyzed disease severity, inflammation markers, and dynamic changes in cartilage glycoprotein 39 (YKL-40) and C-reactive protein (CRP) levels in children with sepsis before and after treatment with continuous blood purification (CBP). Study participants were 30 children with severe sepsis who were cured from the disease (experimental group) in the Children’s Serious Disease Center of In­ner Mongolia People’s Hospital between June 2012 and October 2013. Symptomatic CBP treatment was performed after disease severity scor­ing. Interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), YKL-40, and CRP levels were tested 0, 12, 24, and 48 h after CBP treatment. YKL-40 mRNA expression in whole blood was determined biochemi­cally, and its expression in peripheral blood was determined with an immunochemical method. We found a significant difference in disease severity scores before and 48 h after CBP treatment (P

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