Research Article

Polymorphisms in the PPARγ gene and their association with metabolic syndrome in Uyghurs and Kazakhs from Xinjiang, China

Published: June 11, 2015

Genet. Mol. Res. 14 (2) : 6279-6288 DOI: https://doi.org/10.4238/2015.June.11.1

Cite this Article:

J. Chen, R.L. Ma, H. Guo, Y.S. Ding, J.Y. Zhang, J.M. Liu, M. Kerm, M. Zhang, S.Z. Xu, S.G. Li, S.X. Guo (2015). Polymorphisms in the PPARγ gene and their association with metabolic syndrome in Uyghurs and Kazakhs from Xinjiang, China. Genet. Mol. Res. 14(2): 6279-6288. https://doi.org/10.4238/2015.June.11.1

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Abstract

We investigated the association between polymorphisms rs1801282 and rs3856806 of the PPARγ gene and metabolic syndrome (MS) among Uyghurs and Kazakhs. Mass spectrometry techniques were used to detect the PPARγ genotypes rs1801282 and rs3856806 in 987 subjects, CC genotype and C allele frequencies were 83.6 and 91.7%, respectively, at rs1801282 in Kazakhs, which were higher than those in Uyghurs (72.3 and 85.0%, respectively; P

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