Cytotoxicity of 1-dodecyl-3-methylimidazolium bromide on HepG2 cells

We evaluated the cytotoxicity of 1-dodecyl-3-methylimidazo­lium bromide ([C₁₂mim][Br]) on HepG2 cells and its influence on plasma membrane permeability. The results showed that [C₁₂mim][Br] inhibited HepG2 cell growth and decreased cell viability in a concentration-depen­dent manner. The results also revealed that [C₁₂mim][Br] exposure induced apoptosis in [C₁₂mim][Br]-treated HepG2 cells. In addition, the results showed that [C₁₂mim][Br] increased membrane permeability in HepG2 cells. These results suggest that plasma membrane permeability may be responsible for apoptosis induced by [C₁₂mim][Br] in HepG2 cells.