Research Article

Significance of TNF-α and IL-6 expression in invasive pituitary adenomas

Published: March 22, 2016

Genet. Mol. Res. 15(1): gmr7502 DOI: https://doi.org/10.4238/gmr.15017502

Cite this Article:

J.L. Wu, J.Y. Qiao, Q.H. Duan, J.L. Wu, J.Y. Qiao, Q.H. Duan, J.L. Wu, J.Y. Qiao, Q.H. Duan (2016). Significance of TNF-α and IL-6 expression in invasive pituitary adenomas. Genet. Mol. Res. 15(1): gmr7502. https://doi.org/10.4238/gmr.15017502

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Abstract

The aim of this study was to investigate expression of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in invasive pituitary adenomas (IPAs). The streptavidin peroxidase immunohistochemical method was employed to detect their expression in 40 cases of IPA and 40 of non-invasive pituitary adenoma (NIPA). TNF-α and IL-6 were found to be upregulated in IPA tissue compared with that of NIPA (P < 0.05). These proteins may therefore play important roles in the occurrence and progression of IPA.

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