Research Article

Correlation between IL-3 and IL-13 gene polymorphisms in Chinese patients and rheumatoid arthritis

Published: May 23, 2016
Genet. Mol. Res. 15(2): gmr7966 DOI: https://doi.org/10.4238/gmr.15027966
Cite this Article:
(2016). Correlation between IL-3 and IL-13 gene polymorphisms in Chinese patients and rheumatoid arthritis. Genet. Mol. Res. 15(2): gmr7966. https://doi.org/10.4238/gmr.15027966
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Abstract

The aim of this study was to examine the association between polymorphisms in the interleukin-3 and -13 (IL-3 and IL-13) genes and rheumatoid arthritis (RA). In this hospital-based case-control study, we analyzed the IL-3 rs2073506 G/A, IL-3 rs40401 C/T, and IL-13 rs1800925 C/T polymorphisms in 615 RA patients and 839 controls from a Chinese Han population. Genotyping was performed using a custom-by-design 48-Plex single nucleotide polymorphism scanTM kit. Our results indicated that the IL-3 rs2073506 G/A, IL-3 rs40401 C/T, and IL-13 rs1800925 C/T polymorphisms were not associated with RA. However, stratification analyses suggested that the IL-13 rs1800925 CT and CT/CC genotypes increased the risk of RA in patients with erythrocyte sedimentation rate (ESR) IL-13 rs1800925 C/T polymorphism may be associated with increased risk of RA in ESR

The aim of this study was to examine the association between polymorphisms in the interleukin-3 and -13 (IL-3 and IL-13) genes and rheumatoid arthritis (RA). In this hospital-based case-control study, we analyzed the IL-3 rs2073506 G/A, IL-3 rs40401 C/T, and IL-13 rs1800925 C/T polymorphisms in 615 RA patients and 839 controls from a Chinese Han population. Genotyping was performed using a custom-by-design 48-Plex single nucleotide polymorphism scanTM kit. Our results indicated that the IL-3 rs2073506 G/A, IL-3 rs40401 C/T, and IL-13 rs1800925 C/T polymorphisms were not associated with RA. However, stratification analyses suggested that the IL-13 rs1800925 CT and CT/CC genotypes increased the risk of RA in patients with erythrocyte sedimentation rate (ESR) IL-13 rs1800925 C/T polymorphism may be associated with increased risk of RA in ESR

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