Research Article

A comprehensive review of microRNA-related polymorphisms in gastric cancer

Published: July 14, 2016
Genet. Mol. Res. 15(2): gmr8289 DOI: https://doi.org/10.4238/gmr.15028289
Cite this Article:
B.W. Han, Z.H. Li, S.F. Liu, H.B. Han, S.J. Dong, H.J. Zou, R.F. Sun, J. Jia, B.W. Han, Z.H. Li, S.F. Liu, H.B. Han, S.J. Dong, H.J. Zou, R.F. Sun, J. Jia (2016). A comprehensive review of microRNA-related polymorphisms in gastric cancer. Genet. Mol. Res. 15(2): gmr8289. https://doi.org/10.4238/gmr.15028289
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Abstract

MicroRNAs (miRNAs) are a class of small non-coding RNA molecules of about 22 nucleotides in length. miRNAs are highly conserved in both plants and animals, and function as gene regulators by binding to the 3'-untranslated region of target mRNAs for cleavage and/or translational repression. miRNA biogenesis, stability, and regulation of expression are strongly sequence dependent. Sequence variants, such as single nucleotide polymorphisms (SNPs) in pri-miRNA, pre-miRNA, promoter regions, or miRNA-target sites, can influence miRNA function, thereby contributing to the pathological features of human disease. In this review, we focus on miRNA-related SNPs in gastric cancer and comprehensively analyze some commonly studied SNPs.

MicroRNAs (miRNAs) are a class of small non-coding RNA molecules of about 22 nucleotides in length. miRNAs are highly conserved in both plants and animals, and function as gene regulators by binding to the 3'-untranslated region of target mRNAs for cleavage and/or translational repression. miRNA biogenesis, stability, and regulation of expression are strongly sequence dependent. Sequence variants, such as single nucleotide polymorphisms (SNPs) in pri-miRNA, pre-miRNA, promoter regions, or miRNA-target sites, can influence miRNA function, thereby contributing to the pathological features of human disease. In this review, we focus on miRNA-related SNPs in gastric cancer and comprehensively analyze some commonly studied SNPs.