Research Article

Growth factor progranulin blocks tumor necrosis factor-α-mediated inhibition of osteoblast differentiation

Published: September 09, 2016
Genet. Mol. Res. 15(3): gmr8126 DOI: https://doi.org/10.4238/gmr.15038126
Cite this Article:
(2016). Growth factor progranulin blocks tumor necrosis factor-α-mediated inhibition of osteoblast differentiation. Genet. Mol. Res. 15(3): gmr8126. https://doi.org/10.4238/gmr.15038126
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Abstract

Tumor necrosis factor-α (TNF-α) stimulates osteoclast differentiation and suppresses osteoblast differentiation, leading to bone loss and decreased bone mass in local inflammation areas in patients with rheumatoid arthritis. The growth factor progranulin (PGRN) is expressed in various types of cells and play crucial roles in the pathogenesis of atherosclerosis and arthritis by blocking TNF-α. Here, we investigated the role of PGRN in blocking TNF-α-mediated inhibition of osteoblast differentiation and the regulatory mechanism. C2C12 stem cell was induced by bone morphogenetic protein-2 (BMP-2) for osteoblast differentiation. A significant increase in ALP activity (P ColI, Ocn, and Bsp in the induced cells (P ColI, Ocn, and Bsp (P Runx2 (P Osx (P ATF4 (P

Tumor necrosis factor-α (TNF-α) stimulates osteoclast differentiation and suppresses osteoblast differentiation, leading to bone loss and decreased bone mass in local inflammation areas in patients with rheumatoid arthritis. The growth factor progranulin (PGRN) is expressed in various types of cells and play crucial roles in the pathogenesis of atherosclerosis and arthritis by blocking TNF-α. Here, we investigated the role of PGRN in blocking TNF-α-mediated inhibition of osteoblast differentiation and the regulatory mechanism. C2C12 stem cell was induced by bone morphogenetic protein-2 (BMP-2) for osteoblast differentiation. A significant increase in ALP activity (P ColI, Ocn, and Bsp in the induced cells (P ColI, Ocn, and Bsp (P Runx2 (P Osx (P ATF4 (P

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