Research Article

Effects of Moquiniastrum polymorphum ssp floccosum ethnolic extract on colorectal carcinogenesis induced by 1,2-dimethylhydrazine.

Published: March 16, 2017
Genet. Mol. Res. 16(1): gmr16019518 DOI: https://doi.org/10.4238/gmr16019518
Cite this Article:
S.M.A. Limeiras, B.C. Oliveira, L.R. Pessatto, J.R. Pesarini, C.A.L. Kassuya, A.C.D. Monreal, W.B. Cantero, R. Antoniolli-Silva, A.C.M.B. Antoniolli-Silva, M.E.A. Stefanello, R.J. Oliveira (2017). Effects of Moquiniastrum polymorphum ssp floccosum ethnolic extract on colorectal carcinogenesis induced by 1,2-dimethylhydrazine.. Genet. Mol. Res. 16(1): gmr16019518. https://doi.org/10.4238/gmr16019518
2,156 views

Abstract

The objective of this study was to evaluate the effect of Moquiniastrum polymorphum ssp floccosum ethanolic extract (MPEE) on 1,2 dimethylhydrazine (DMH)-induced colorectal carcinogenesis in mice. Forty-two male Swiss mice (Mus musculus) were subdivided into six groups (N = 7/group): negative control, DMH, MPEE, pre-treatment, simultaneous, and post-treatment. Results showed that MPEE has antigenotoxic potential on the tested protocols pre- and silmultaneous treatment, and the percent damage reductions (%DRs) were 81.88 and 93.12%, respectively. The micronucleus test demonstrated that MPEE has great antimutagenic activity, with %DRs higher than 77.09 in the associated groups. The aberrant crypt focus assay demonstrated anticarcinogenic potential of MPEE as the associated groups showed %DRs that ranged from 62.13 to 95.14%. The study shows that MPEE is nontoxic and has chemopreventive and anticarcinogenic activity, thus it may prove to be a promising medicinal plant in view of its demonstrated properties.

Download: