Research Article

Use of transoral CO2 laser microsurgery for treatment of cancerous neoplasms of the larynx in Vietnam

Published: March 25, 2021
Genet. Mol. Res. 20(1): GMR18734 DOI:


Laryngeal cancer remains one of the most common head and neck tumors. In the treatment of this disease, it is important to assess the overall survival when using transoral СО2 laser microsurgery. The aim of the research was to make an evaluation of treatment of patients with laryngeal cancer undergoing CO2 laser transoral microsurgery. Fifty patients aged 40-82 years (average age 58.7 years) with early-stage laryngeal cancer were treated with СО2 laser transoral microsurgery at the National ENT hospital from January 2012 to August 2014.Tumors at the T1aN0M0 stage were detected in 68%, T1bN0M0 in 14%, T2N0M0 in 18%. Overall survival was 87.1 ± 2.3 months, and 5-year survival was 92%. The survival rate depending on the type of surgical intervention Type III, Type IV, Type Va, Type Vb, Type Vc was 93, 94, 100, 100, and 100%, respectively. The survival rate depending on the stage T1aN0M0 was 91%, on the stage T1bN0M0 was 100%, on the stage T2N0M0 was 88%. Transoral СО2 laser microsurgery shows excellent results in laryngeal tumors, especially in the T1aN0M0 stage, making it possible to perform surgery in more comfortable conditions; it provides high survival rates, excellent cosmetic and functional results compared to classical open access, without compromising immediate and long-term treatment results.