5-Fluorouracil

5-Fluorouracil induces apoptosis of colorectal cancer cells

J. T. Zhang, Zhou, W. L., He, C., Liu, T., Li, C. Y., Wang, L., Zhang, J. T., Zhou, W. L., He, C., Liu, T., Li, C. Y., and Wang, L., 5-Fluorouracil induces apoptosis of colorectal cancer cells, vol. 15, p. -, 2016.

5-Fluorouracil (5-FU) is widely used in chemotherapy for treatment of colorectal cancer. Leucine-rich repeat-containing G protein-coupled receptor (LGR) is known to participate in the occurrence and development of breast cancer by regulating the rebirth of tumor vessels. This study aimed to explore the proliferation and apoptosis of HCT116 colorectal cancer cells treated with 5-FU and related molecular mechanisms. 5-FU (20 μg/mL) was used to treat cultured HCT116 cells.

Study on the ERCC1 gene polymorphism response to chemotherapy and prognosis of gastric cancer

L. Liu, Li, C. H., Jin, T. F., and Xu, D. Y., Study on the ERCC1 gene polymorphism response to chemotherapy and prognosis of gastric cancer, vol. 13, pp. 8722-8728, 2014.

We conducted a cohort study to investigate the role of 2 single-nucleotide polymorphisms of the excision repair cross-complimentary group 1 (ERCC1) gene polymorphism in response to chemotherapy and clinical outcomes of gastric cancer. A total of 231 patients with newly diagnosed and histopathologically confirmed primary gastric cancer participated in the study. ERCC1 rs11615 and rs3212986 were genotyped. Individuals with the ERCC1 rs11615 TT genotype and the T allele showed a significant poorer response to chemotherapy compared to the wild-type genotype.

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