A1298C

Lack of association between the methylenetetrahydropholate reductase gene A1298C polymorphism and neural tube defects in a Turkish study group

S. H. Yildiz, M. Erdogan, O., Solak, M., Eser, O., Terzi, E. S. Arıkan, Eser, B., Kocabaş, V., Aslan, A., Yildiz, S. H., M. Erdogan, O., Solak, M., Eser, O., Terzi, E. S. Arıkan, Eser, B., Kocabaş, V., and Aslan, A., Lack of association between the methylenetetrahydropholate reductase gene A1298C polymorphism and neural tube defects in a Turkish study group, vol. 15, p. -, 2016.

The etiology underlying neural tube defects (NTDs) is not fully understood and is believed to involve a complex milieu of genetic and environmental factors. The A1298C polymorphism in the methylenetetrahydropholate reductase gene (MTHFR) has been associated with mild risk for NTDs. In this study, the genotype distribution of the MTHFR gene A1298C polymorphism and the levels of serum homocysteine, vitamin B12, and folate were evaluated in 33 children with NTDs, their mothers, and 46 healthy controls.

Association between C677T and A1298C polymorphisms of the MTHFR gene and risk of male infertility: a meta-analysis

Y. Yang, Luo, Y. Y., Wu, S., Tang, Y. D., Rao, X. D., Xiong, L., Tan, M., Deng, M. Z., Liu, H., Yang, Y., Luo, Y. Y., Wu, S., Tang, Y. D., Rao, X. D., Xiong, L., Tan, M., Deng, M. Z., Liu, H., Yang, Y., Luo, Y. Y., Wu, S., Tang, Y. D., Rao, X. D., Xiong, L., Tan, M., Deng, M. Z., and Liu, H., Association between C677T and A1298C polymorphisms of the MTHFR gene and risk of male infertility: a meta-analysis, vol. 15, p. -, 2016.

Published studies on the association between the C677T and A1298C polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene and male infertility risk are controversial. To obtain a more precise evaluation, we performed a meta-analysis based on published case-control studies. We conducted an electronic search of PubMed, EMBASE, the Cochrane Library, the Web of Science, and the China Knowledge Resource Integrated Database for papers on MTHFR gene C677T and A1298C polymorphisms and male infertility risk.

MTHFR C677T and A1298C polymorphisms and risk of lung cancer: a comprehensive evaluation

Y. Yang, Yang, L. J., Deng, M. Z., Luo, Y. Y., Wu, S., Xiong, L., Wang, D., Liu, Y., Liu, H., Yang, Y., Yang, L. J., Deng, M. Z., Luo, Y. Y., Wu, S., Xiong, L., Wang, D., Liu, Y., Liu, H., Yang, Y., Yang, L. J., Deng, M. Z., Luo, Y. Y., Wu, S., Xiong, L., Wang, D., Liu, Y., and Liu, H., MTHFR C677T and A1298C polymorphisms and risk of lung cancer: a comprehensive evaluation, vol. 15, p. -, 2016.

Results from previous studies on the association between methylenetetrahydrofolate reductase (MTHFR) polymorphisms C677T and A1298C and lung cancer have been conflicting. The aim of this meta-analysis was to clarify the effect of MTHFR polymorphisms on the risk of lung cancer. An electronic search of PubMed, EMBASE, the Cochrane library, and the China Knowledge Resource Integrated Database for papers on C677T and A1298C and susceptibility to lung cancer was performed. The STATA software (Version 13.0) was used for statistical analysis.

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