A20 gene

Zinc finger protein A20 overexpression inhibits monocyte homing and protects endothelial cells from injury induced by high glucose

C. L. Hou, Zhang, W., Wei, Y., Mi, J. H., Li, L., Zhou, Z. H., Zeng, W., and Ying, D. J., Zinc finger protein A20 overexpression inhibits monocyte homing and protects endothelial cells from injury induced by high glucose, vol. 10, pp. 1050-1059, 2011.

Diabetes mellitus causes vascular lesions and may ultimately lead to atherosclerosis. One of the earliest steps in the development of atherosclerotic lesions is the adhesion of monocytes to endothelial cells of the vessel wall. It is currently unknown whether zinc finger protein A20 is able to protect endothelial cells from injury caused by high levels of glucose and monocyte homing. In our study, adhesion of monocytes to the vessel wall endothelium was detected by measuring the rolling velocity of monocytes along human umbilical vein endothelial cells (HUVECs).

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