Acellular cartilaginous matrix

Repair of articular cartilage defects by tissue-engineered cartilage constructed with adipose-derived stem cells and acellular cartilaginous matrix in rabbits

Z. J. Wang, An, R. Z., Zhao, J. Y., Zhang, Q., Yang, J., Wang, J. B., Wen, G. Y., Yuan, X. H., Qi, X. W., Li, S. J., and Ye, X. C., Repair of articular cartilage defects by tissue-engineered cartilage constructed with adipose-derived stem cells and acellular cartilaginous matrix in rabbits, vol. 13, pp. 4599-4606, 2014.

After injury, inflammation, or degeneration, articular cartilage has limited self-repair ability. We aimed to explore the feasibility of repair of articular cartilage defects with tissue-engineered cartilage constructed by acellular cartilage matrices (ACMs) seeded with adipose-derived stem cells (ADSCs). The ADSCs were isolated from 3-month-old New Zealand albino rabbit by using collagenase and cultured and amplified in vitro.

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