Adenocarcinoma

Identifying differentially expressed genes and pathways in two types of non-small cell lung cancer: adenocarcinoma and squamous cell carcinoma

J. Liu, Yang, X. Y., and Shi, W. J., “Identifying differentially expressed genes and pathways in two types of non-small cell lung cancer: adenocarcinoma and squamous cell carcinoma”, vol. 13, pp. 95-102, 2014.

Non-small cell lung carcinoma, NSCLC, accounts for 80-85% of lung cancers. NSCLC can be mainly divided into two types: adenocarcinoma (ADC) and squamous cell carcinoma (SCC). The purpose of our study was to identify and differentiate the pathogenesis of ADC and SCC at the molecular level. The gene expression profiles of ADC and SCC were downloaded from Gene Expression Omnibus under accession No. GSE10245. Accordingly, differentially expressed genes (DEGs) were identified by the limma package in R language.

Bicluster and regulatory network analysis of differentially expressed genes in adenocarcinoma and squamous cell carcinoma

L. Li, Zhu, J., Guo, S. - X., and Deng, Y., “Bicluster and regulatory network analysis of differentially expressed genes in adenocarcinoma and squamous cell carcinoma”, vol. 12, pp. 1710-1719, 2013.

Squamous cell carcinoma (SCC) and adenocarcinoma (AC) are the major histological types of non-small cell lung cancer (NSCLC). Although differences in molecular, histological, and clinical characteristics have been reported for both subtypes, no specific therapy exists thus far. The aim of this analysis was to identify potential therapeutic target genes that are specific to SCC and AC. We used microarray data to analyze the global gene expression profile of 58 human NSCLC specimens. We identified more than 2400 genes that were differentially expressed in SCC and AC.

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