Alzheimer’s disease

Estrogen receptor 1 PvuII and XbaI polymorphisms and susceptibility to Alzheimer’s disease: a meta-analysis

Y. H. Lee and Song, G. G., “Estrogen receptor 1 PvuII and XbaI polymorphisms and susceptibility to Alzheimer’s disease: a meta-analysis”, vol. 14, pp. 9361-9369, 2015.

The aim of this study was to explore whether estrogen receptor 1 (ESR1) PvuII and XbaI polymorphisms are associated with susceptibility to Alzheimer’s disease (AD). We conducted a meta-analysis of the associations between AD and ESR1 PvuII and XbaI polymorphisms as well as haplotypes of the ESR1 PvuII and XbaI polymorphisms.

Association of PS1 1/2, ACE I/D, and LRP C/T polymorphisms with Alzheimer’s disease in the Chinese population: a meta-analysis of case-control studies

L. Yang, Zhou, H. - H., Ye, Y. - F., Fan, X. - W., Wang, Y. - J., and Meng, Y., “Association of PS1 1/2, ACE I/D, and LRP C/T polymorphisms with Alzheimer’s disease in the Chinese population: a meta-analysis of case-control studies”, vol. 14, pp. 1017-1024, 2015.

The objective of this study was to assess the associations of presenilin 1 (PS1) 1/2, angiotensin I-converting enzyme (ACE) insertion/deletion (I/D), and low-density lipoprotein receptor-related protein (LRP) C/T polymorphisms with the risk of Alzheimer’s disease (AD) in the Chinese population. PS1 1/2, ACE I/D, and LRP C/T, which are commonly investigated polymorphisms, were evaluated to obtain summary estimates regarding their associations with AD.

Potential hippocampal genes and pathways involved in Alzheimer’s disease: a bioinformatic analysis

L. Zhang, Guo, X. Q., Chu, J. F., Zhang, X., Yan, Z. R., and Li, Y. Z., “Potential hippocampal genes and pathways involved in Alzheimer’s disease: a bioinformatic analysis”, vol. 14, pp. 7218-7232, 2015.

Alzheimer’s disease (AD) is a neurodegenerative disor­der and the most common cause of dementia in elderly people. Nu­merous studies have focused on the dysregulated genes in AD, but the pathogenesis is still unknown. In this study, we explored critical hippocampal genes and pathways that might potentially be involved in the pathogenesis of AD.

PPARγ Pro12Ala and His447His polymorphisms and susceptibility to Alzheimer’s disease: a meta-analysis

Y. H. Lee and Song, G. G., “PPARγ Pro12Ala and His447His polymorphisms and susceptibility to Alzheimer’s disease: a meta-analysis”, vol. 14, pp. 7248-7257, 2015.

We investigated whether Pro12Ala (C→G) and His447His (C→T) polymorphisms of the peroxisome proliferator-activated receptor gamma (PPARγ) gene are associated with susceptibility to Alzheimer’s disease (AD). We conducted a meta-analysis of the associations between the PPARγ Pro12Ala and His447His polymorphisms and AD in subjects. The meta-analysis was performed according to the apolipoprotein E (APOE) ɛ4 allele status. A total of eight studies were considered in our meta-analysis, comprising 2948 patients with AD and 3753 controls.

Effects of curcumin on hippocampal expression of NgR and axonal regeneration in Aβ-induced cognitive disorder rats

H. L. Yin, Wang, Y. L., Li, J. F., Han, B., Zhang, X. X., Wang, Y. T., and Geng, S., “Effects of curcumin on hippocampal expression of NgR and axonal regeneration in Aβ-induced cognitive disorder rats”, vol. 13, pp. 2039-2047, 2014.

Curcumin has been widely used for the prevention and treatment of Alzheimer's disease (AD), but its mechanism is still not clear. Inhibitory factors of axonal regeneration have been shown to cause a series of pathophysiological changes in the early period of AD. In this study, the co-receptor (Nogo receptor; NgR) of three axonal growth-inhibitory proteins was examined, and effects of curcumin on spatial learning and memory abilities and hippocampal axonal growth were investigated in amyloid β-protein (Aβ)1-40-induced AD rats.

Ginsenoside Rh2 promotes nonamyloidgenic cleavage of amyloid precursor protein via a cholesterol-dependent pathway

J. Qiu, Li, W., Feng, S. H., Wang, M., and He, Z. Y., “Ginsenoside Rh2 promotes nonamyloidgenic cleavage of amyloid precursor protein via a cholesterol-dependent pathway”, vol. 13, pp. 3586-3598, 2014.

Ginsenoside Rh2 (Rh2) is a ginseng derivative used in Chinese traditional medicine. We investigated whether Rh2 can help prevent Alzheimer’s disease symptoms and examined underlying mechanisms. We injected Rh2 into tg2576 Alzheimer’s disease model mice and looked for behavioral improvement and senile plaque reduction in brain slices. We measured amyloid precursor protein (APP) metabolism species changes, amyloid beta40 and 42 levels and β, γ secretase activity in primary hippocampal neurons. By living cell staining, we detected surface and endocytosed APP.

Effect of the beta secretase-1 inhibitor on the amyloid C-terminal fragment of amyloid precursor protein processing in a hyperphosphorylated tau rat model

H. Y. Chen, Wang, L., Liu, J. F., Wang, W. Z., and Yu, C. J., “Effect of the beta secretase-1 inhibitor on the amyloid C-terminal fragment of amyloid precursor protein processing in a hyperphosphorylated tau rat model”, vol. 13, pp. 6213-6227, 2014.

The amyloid C-terminal fragment (βCTF) of the amyloid precursor protein (APP) is the cleaved component of APP by beta secretase-1 (BACE1), which shows similar neurotoxicity as amyloid beta (Aβ) in many ways. Evidence suggested that in addition to Aβ, βCTF might also participate in the pathogenesis of Alzheimer’s disease (AD). In recent years, the relationship between βCTF processing and hyperphosphorylated tau has attracted increasing research attention.

Polymorphism of the OLR1 3'UTR potential microRNA binding site and risk of Alzheimer’s disease: a meta-analysis

Y. Kong, Wu, J. B., Wang, X., Zhao, J. F., Song, H., and Yuan, L. D., “Polymorphism of the OLR1 3'UTR potential microRNA binding site and risk of Alzheimer’s disease: a meta-analysis”, vol. 13, pp. 10162-10172, 2014.

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that contributes to dementia in the elderly population. Genome-wide linkage analysis has identified chromosome 12p as the AD-susceptible region, which includes lectin-like oxidized low-density lipoprotein receptor 1 (OLR1). The OLR1 +1073 C/T single-nucleotide polymorphism is located in the 3'-untranslated region of the gene and may influence the binding of regulatory microRNAs (miRNAs) and OLR1 protein homeostasis. A number of studies have reported an association between this variant and AD.

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