Angiotensin-converting enzyme

Traditional risk factors and angiotensin-converting enzyme insertion/deletion gene polymorphism in coronary artery disease

S. Sahin, Ceyhan, K., Benli, I., Ozyurt, H., Naseri, E., Tumuklu, M. M., Aydogan, L., Elalmis, A. O., Ozugurlu, A. F., and Onalan, O., Traditional risk factors and angiotensin-converting enzyme insertion/deletion gene polymorphism in coronary artery disease, vol. 14, pp. 2063-2068, 2015.

We investigated whether the insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme (ACE) gene and serum ACE levels are associated with traditional risk factors of coronary artery disease (CAD). We enrolled 250 individuals without CAD and 750 individuals suffering from CAD who were angiographically diagnosed. Biochemical risk factors, the ACE (I/D) gene polymorphism, and ACE serum levels were compared. ACE genotypes were determined using real-time polymerase chain reaction.

Meta-analytical association between angiotensin-converting enzyme gene polymorphisms and sarcoidosis risk

R. Zhu, Bi, L. Q., Kong, H., Tilley, S. L., Wang, H., and Xie, W. P., Meta-analytical association between angiotensin-converting enzyme gene polymorphisms and sarcoidosis risk, vol. 14, pp. 3590-3600, 2015.

Previous reports identified an association between sarcoidosis and an insertion/deletion (I/D) polymorphism in angiotensin-converting enzyme. Our meta-analysis of articles published between March 1996 and June 2013 identified studies in the PubMed, EMBASE, and the China National Knowledge Infrastructure databases. We examined whether angiotensin-converting enzyme polymorphisms influence sarcoidosis susceptibility. The strength of the association between I/D polymorphisms and sarcoidosis risk was measured based on the odds ratio and 95% confidence interval.

Angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to systemic sclerosis: a meta-analysis

G. G. Song and Lee, Y. H., Angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to systemic sclerosis: a meta-analysis, vol. 13, pp. 8174-8183, 2014.

The purpose of this study was to examine whether the insertion (I) or deletion (D) polymorphism of the angiotensin-converting enzyme gene (ACE) is associated with susceptibility to systemic sclerosis (SSc). A meta-analysis examining the associations between the ACE I/D polymorphism and SSc was conducted in overall and European populations using 1) allelic contrast (D vs I); 2) recessive (DD vs ID + II); 3) dominant (DD + ID vs II); and 4) additive (DD vs ID vs II) models.

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