Angiotensin-converting enzyme

Angiotensin-converting enzyme gene polymorphism (insertion/deletion) and liver fibrosis in Turkish patients from the western Black Sea region, Turkey

N. K. Turhan, S. Ilikhan, U., Hamamcioglu, A. C., Ustundag, Y., Dursun, A., and Kokturk, F., Angiotensin-converting enzyme gene polymorphism (insertion/deletion) and liver fibrosis in Turkish patients from the western Black Sea region, Turkey, vol. 14, pp. 17079-17090, 2015.

Chronic viral hepatitis B, chronic viral hepatitis C, non-alcoholic steatohepatitis, alcoholic liver disease, autoimmune hepatitis, primary biliary cirrhosis, and secondary biliary cirrhosis are important health issues worldwide. While an association between angiotensin-converting enzyme gene insertion/deletion (ACE gene I/D) polymorphism and liver fibrosis has been demonstrated in rat studies, the results of clinical studies area have been contradictory.

Lack of association between potential prothrombotic genetic risk factors and arterial and venous thrombosis

F. C. G. Evangelista, Rios, D. R. A., Ribeiro, D. D., Carvalho, M. G., Dusse, L. M. S., Fernandes, A. P., and Sabino, A. P., Lack of association between potential prothrombotic genetic risk factors and arterial and venous thrombosis, vol. 14, pp. 9585-9594, 2015.

Recent studies have shown an association between thrombosis and factor VII (FVII), tissue factor (TF), and angiotensin-converting enzyme (ACE). This suggests that individuals with FVII-402 G/A, FVII-401 G/T, TF+5466 A/G, and ACE-287 insertion/deletion (I/D) polymorphisms present an increased risk of venous thrombosis, heart disease, and ischemic stroke compared with controls. In this study, we investigated the frequencies of these polymorphisms and their association with arterial and venous thrombosis.

Correlation between single nucleotide polymorphisms in hypoxia-related genes and susceptibility to acute high-altitude pulmonary edema

A. L. Wu, Xiong, Y. S., Li, Z. Q., Liu, Y. G., Quan, Q., and Wu, L. J., Correlation between single nucleotide polymorphisms in hypoxia-related genes and susceptibility to acute high-altitude pulmonary edema, vol. 14, pp. 11562-11572, 2015.

This study aimed to explore the relationship between genetic changes and high-altitude pulmonary edema (HAPE) susceptibility, and to screen for the key single nucleotide polymorphism (SNP) loci in the HAPE-susceptibility gene, by investigating the SNPs occurring in hypoxia-related genes in HAPE-susceptible and control (non-susceptible) populations. This research was conducted on Han recruits, who travelled to the Lhasa plateau (altitude, 3658 m).

Subscribe to Angiotensin-converting enzyme