Anti-proliferation

MicroRNA-199a-3p is downregulated in gastric carcinomas and modulates cell proliferation

W. Peng, Chen, Z. - Y., Wang, L., Wang, Z., and Li, J., MicroRNA-199a-3p is downregulated in gastric carcinomas and modulates cell proliferation, vol. 12, pp. 3038-3047, 2013.

MicroRNAs (miRNAs) are small non-coding RNAs that regulate the translation of targeted mRNAs. An increasing amount of evidence indicates that miRNAs play important role in cancer pathogenesis, apoptosis, proliferation, and differentiation as oncogenes or tumor suppressors. Recently, miRNA-199a has been shown to be involved in many human cancers, although the role of miRNA-199a-3p in gastric cancer has not yet been evaluated. In the present study, the expression of miRNA-199a-3p was found to be significantly downregulated in human gastric cancer tissues and cells.

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