Antioxidant

Thunbergia laurifolia extract minimizes the adverse effects of toxicants by regulating P-glycoprotein activity, CYP450, and lipid metabolism gene expression in HepG2 cells

A. Rocejanasaroj, Tencomnao, T., and Sangkitikomol, W., Thunbergia laurifolia extract minimizes the adverse effects of toxicants by regulating P-glycoprotein activity, CYP450, and lipid metabolism gene expression in HepG2 cells, vol. 13, pp. 205-219, 2014.

Thunbergia laurifolia (TL) is widely used as an antidote in Thai traditional medicine against toxic substances such as alcohol, pesticides, arsenic, and strychnine. We found that the lyophilized form of TL in 80% ethanol possessed the antioxidant levels within the range 23,163.9 ± 1457.4 Trolox equivalents mM/kg dry mass and 899.8 ± 14.5 gallic acid equivalents mM/kg dry mass using the oxygen radical absorbance capacity assay and the Folin Ciocalteu phenol assay, respectively.

Effect of Moringa oleifera on advanced glycation end-product formation and lipid metabolism gene expression in HepG2 cells

W. Sangkitikomol, Rocejanasaroj, A., and Tencomnao, T., Effect of Moringa oleifera on advanced glycation end-product formation and lipid metabolism gene expression in HepG2 cells, vol. 13, pp. 723-735, 2014.

In Thai traditional medicine, Moringa oleifera is used for the treatment of diabetes and hyperlipidemia. Oxidative stress plays a major role in the pathogenesis of many degenerative diseases, such as hyperlipidemia, diabetes mellitus, and cardiovascular disease. We evaluated the antioxidant effect of M. oleifera extract (MOE) for reduction of advanced glycation end-product (AGE) formation, cell viability, oxidative stress, and lipid metabolism gene expression in HepG2 cells.

Evaluation of glutathione peroxidase and superoxide dismutase enzyme polymorphisms in celiac disease patients

M. Katar, Ozugurlu, A. F., Ozyurt, H., and Benli, I., Evaluation of glutathione peroxidase and superoxide dismutase enzyme polymorphisms in celiac disease patients, vol. 13, pp. 1030-1037, 2014.

Celiac disease (CD) is a multifactorial, inflammatory small bowel disorder characterized by nutrient malabsorption resulting from mucosal damage, the latter induced by cereal products like barley, oat, and wheat. Oxidative stress has previously been reported to play an important role in the pathogenesis of CD.

Antigenotoxic and antimutagenic effects of glutamine supplementation on mice treated with cisplatin

J. R. Pesarini, Victorelli, S. G., Vicentini, A. P., Ferreira, L. K., Mauro, M. O., Matuo, R., Oliveira, J. R., Antoniolli, A. C. M. B., Mantovani, M. S., and Oliveira, R. J., Antigenotoxic and antimutagenic effects of glutamine supplementation on mice treated with cisplatin, vol. 13, pp. 4820-4830, 2014.

We evaluated the effects of glutamine on clastogenic and genotoxic damage prevention caused by the administration of cisplatin. Forty Swiss mice were divided into 8 experimental groups: G1 and G2, which were control groups; G3, G4, and G5, which were administered [2 doses of glutamine (orally)] separated by a 24-h period (150, 300, and 600 mg/kg, respectively), and a dose of phosphate-buffered saline by intraperitoneal injection; G6, G7, and G8, which were treated in the same manner as the previous groups, but received cisplatin rather than phosphate-buffered saline.

Extract from mistletoe, Viscum album L., reduces Hsp27 and 14-3-3 protein expression and induces apoptosis in C6 rat glioma cells

E. Ö. Uçar, Arda, N., and Aitken, A., Extract from mistletoe, Viscum album L., reduces Hsp27 and 14-3-3 protein expression and induces apoptosis in C6 rat glioma cells, vol. 11, pp. 2801-2813, 2012.

Extracts of mistletoe (Viscum album) are intensively used in complementary medicine, but their mechanisms are not fully understood in most cases, and the effects on metabolism have not been investigated in detail. However, some biologically active natural products are well known to provoke unexpected cellular responses. They reduce overexpression of heat shock proteins (Hsps) in cancer cells. The aim of the current study was to determine whether methanolic extract of V.

Mineral content is related to antioxidant and antimutagenic properties of grape juice

C. Dani, Oliboni, L. S., Prá, D., Bonatto, D., Santos, C. E. I., Yoneama, M. L., Dias, J. F., Salvador, M., and Henriques, J. A. P., Mineral content is related to antioxidant and antimutagenic properties of grape juice, vol. 11, pp. 3154-3163, 2012.

Grape juices are an important source of food antioxidants. Unfortunately, there is little data about the mineral composition and the antioxidant, mutagenic and antimutagenic activities of grape juice in eukaryote cells. We evaluated the mineral contents (Mg, Ca, Mn, Fe, Cu, Zn, Si, S, Cl) of grape juices, the antioxidant, mutagenic and/or antimutagenic activities of the juices in the yeast Saccharomyces cerevisiae, and looked for a possible association between mineral content and antioxidant, mutagenic and/or antimutagenic activities of juice samples.

Effects of Thai black sticky rice extract on oxidative stress and lipid metabolism gene expression in HepG2 cells

W. Sangkitikomol, Tencomnao, T., and Rocejanasaroj, A., Effects of Thai black sticky rice extract on oxidative stress and lipid metabolism gene expression in HepG2 cells, vol. 9, pp. 2086-2095, 2010.

Anthocyanins, which are found in some food, including Thai black sticky rice, are reported to have health-promoting properties. Oxidative stress plays a major role in the pathogenesis of many degenerative diseases induced by free radicals, such as cardiovascular disease, stroke and cancer. We evaluated the anthocyanin-rich extract (ARE) from Thai black sticky rice for antioxidative and antihyperlipidemic effects on HepG2 cells. Cell viability was investigated with the neutral red assay and the MTT assay, and oxidative stress was determined by the DCFH-DA assay.

Antioxidant effect of haptoglobin phenotypes against DNA damage induced by hydrogen peroxide in human leukocytes

L. R. S. Moreira, Miranda-Vilela, A. L., Silva, I. C. R., Akimoto, A. K., Klautau-Guimarães, M. N., and Grisolia, C. K., Antioxidant effect of haptoglobin phenotypes against DNA damage induced by hydrogen peroxide in human leukocytes, vol. 8, pp. 284-290, 2009.

Human haptoglobin is classified into three major phenotypes: Hp1-1, Hp2-1 and Hp2-2; there are two autosomal alleles Hp*1 and Hp*2, and the Hp*1 allele has two subtypes, Hp*1F and Hp*1S. Haptoglobin acts as an antioxidant, preventing hemoglobin-driven oxidative damage. We used the comet assay to examine oxidative damage to DNA induced by hydrogen peroxide in human leukocytes; we also looked for differences in the antioxidant capacity of haptoglobin subtypes.

Oxidative stress response in Paracoccidioides brasiliensis

É. G. Campos, Dantas, Ada Silva, Brigido, Mde Macedo, Brigido, Mde Macedo, Felipe, M. Sueli S., and Jesuino, R. Santos Amo, Oxidative stress response in Paracoccidioides brasiliensis, vol. 4, pp. 409-429, 2005.

Survival of pathogenic fungi inside human hosts depends on evasion from the host immune system and adaptation to the host environment. Among different insults that Paracoccidioides brasiliensis has to handle are reactive oxygen and nitrogen species produced by the human host cells, and by its own metabolism. Knowing how the parasite deals with reactive species is important to understand how it establishes infection and survives within humans. The initiative to describe the P.

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