APC

Characterization of gene methylation in human papillomavirus associated-head and neck squamous cell carcinoma

H. Z. Zhang, Shan, C. G., Huang, A. P., Wang, J. M., Zhang, H. Z., Shan, C. G., Huang, A. P., and Wang, J. M., Characterization of gene methylation in human papillomavirus associated-head and neck squamous cell carcinoma, vol. 15, p. -, 2016.

Head and neck squamous cell carcinoma (HNSCC) has become one of the most common forms of cancer worldwide. Hypermethylation-induced silencing of tumor-associated gene has been proposed as an important cofactor in cancer pathology. This paper aimed to characterize the gene methylation patterns in human papillomavirus (HPV) associated-HNSCC. TIMP3 and APC methylation status in neoplastic (N = 92) and non-neoplastic tissues (N = 92) of HNSCC as well as their association with HPV infection were investigated via methylation-specific PCR assays.

Male-specific association of the APC rs383830 T allele with the risk of coronary heart disease

J. Y. Zhong, Zheng, X. W., Ye, H. D., Cui, H. B., Du, W. P., Zhang, Z. X., Fei, X. H., Lin, S. Y., Wang, J., Su, J., Chen, X. M., and Duan, S. W., Male-specific association of the APC rs383830 T allele with the risk of coronary heart disease, vol. 14, pp. 11745-11751, 2015.

APC is a tumor suppressor gene that is involved in the processes of cell migration and adhesion, transcriptional activation, and apoptosis. The goal of this study was to evaluate the contribution of the APC rs383830 polymorphism to coronary heart disease (CHD) in Han Chinese. A total of 783 patients with CHD and 737 controls were tested in the current association study.

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