Apoptosis

Mitochondrial dysfunction in resveratrol-induced apoptosis in QGY-7701 cells

J. P. Li, Ma, Q., Chen, C. M., Li, J. P., Ma, Q., Chen, C. M., Li, J. P., Ma, Q., and Chen, C. M., Mitochondrial dysfunction in resveratrol-induced apoptosis in QGY-7701 cells, vol. 15, p. -, 2016.

This study aims to evaluate the cytotoxicity of resveratrol on QGY-7701 cells via a cell viability assay, and determine the cytological alterations and damages that result. Resveratrol was found to inhibit QGY-7701 cell growth and decrease their viability in a remarkably dose-dependent manner. Resveratrol exposure also induced an increase in Caspase-3 activity and a decrease in Bcl-2, which caused an increase in membrane permeability, and the opening of mitochondrial permeability transition pores and mitochondrial depolarization.

Cytotoxic and immunomodulatory effects of Ebenus boissieri Barbey on breast cancer cells

N. Imir, Aydemir, E., Simsek, E., Gokturk, R. S., Yesilada, E., Fiskin, K., Imir, N., Aydemir, E., Simsek, E., Gokturk, R. S., Yesilada, E., Fiskin, K., Imir, N., Aydemir, E., Simsek, E., Gokturk, R. S., Yesilada, E., and Fiskin, K., Cytotoxic and immunomodulatory effects of Ebenus boissieri Barbey on breast cancer cells, vol. 15, p. -, 2016.

We aimed to determine the cytotoxic and immunomodulatory effects of hydroalcoholic extracts of the roots and aerial parts of Ebenus boissieri (EB) on breast cancer MDA-MB231 cells and the non-cancerous human embryonic kidney cell line, 293T. Cell viability was determined by MTT assay, trypan blue exclusion, and Live/Dead Viability/Cytotoxicity assay. Apoptosis was evaluated by measuring the activity of caspase-2, 3, 6, 8, and 9.

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