Asthma

Effect of compound Maqin decoction on TGF-β1/Smad proteins and IL-10 and IL-17 content in lung tissue of asthmatic rats

Y. H. Xie, Li, X. P., Xu, Z. X., Qian, P., Li, X. L., Wang, Y. Q., Xie, Y. H., Li, X. P., Xu, Z. X., Qian, P., Li, X. L., and Wang, Y. Q., Effect of compound Maqin decoction on TGF-β1/Smad proteins and IL-10 and IL-17 content in lung tissue of asthmatic rats, vol. 15, p. -, 2016.

In this research, compound Maqin decoction (CMD) has been shown to positively affect in airway inflammation of asthma models. We evaluated the effects of CMD on the expression of transforming growth factor (TGF)-β1/Smad proteins, interleukin (IL)-17, and IL-10 in lung tissue of asthmatic rats. Asthma was induced in a rat model using ovalbumin. After a 4-week treatment with CMD, rats were killed to evaluate the expression of TGF-β1 and Smad proteins in lung tissue. IL-10 and IL-17 levels in lung tissue homogenates were determined by ELISA.

Polymorphisms in the vascular endothelial growth factor (VEGF) gene associated with asthma

H. Y. Lu, Zhao, G. L., Fu, M. F., Lu, H. Y., Zhao, G. L., and Fu, M. F., Polymorphisms in the vascular endothelial growth factor (VEGF) gene associated with asthma, vol. 15, p. -, 2016.

It has been proven that vascular endothelial growth factor (VEGF) is involved in airway restoration and the development of asthma. We sought to examine the relevance of VEGF gene polymorphisms to asthma in the Chinese Han population. We extracted the whole genomic DNA from the peripheral blood of 471 participants, including 226 patients with asthma and 245 healthy controls. Seven single nucleotide polymorphisms (SNPs) of the VEGF gene were genotyped using the MassARRAY system. The data were then analyzed using HaploView 4.0 and SPSS 20.0 softwares.

Correlation between polymorphisms in the glucocorticoid receptor gene NR3C1 and susceptibility to asthma in a Chinese population from the Henan Province

Z. Cheng, Dai, L. L., Liu, Q., Liu, M., Wang, Q., Li, P. F., Wang, H., Jia, L. Q., An, L., Cheng, Z., Dai, L. L., Liu, Q., Liu, M., Wang, Q., Li, P. F., Wang, H., Jia, L. Q., and An, L., Correlation between polymorphisms in the glucocorticoid receptor gene NR3C1 and susceptibility to asthma in a Chinese population from the Henan Province, vol. 15, p. -, 2016.

The aim of this study was to investigate the association between four single nucleotide polymorphisms in NR3C1 (Tth111I, BclI, ER22/23EK, and N363S), which encode the glucocorticoid receptor, and asthma susceptibility in patients from the Henan Province of China. Three hundred and twenty-eight patients with asthma and 60 healthy volunteers were recruited to this study. The target SNPs were genotyped by polymerase chain reaction (PCR)-high resolution melting and PCR-restriction fragment length polymorphism.

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