Atf2

Acetate ester production by Chinese yellow rice wine yeast overexpressing the alcohol acetyltransferase-encoding gene ATF2

J. Zhang, Zhang, C., Qi, Y., Dai, L., Ma, H., Guo, X., and Xiao, D., Acetate ester production by Chinese yellow rice wine yeast overexpressing the alcohol acetyltransferase-encoding gene ATF2, vol. 13, pp. 9735-9746, 2014.

Acetate ester, which are produced by fermenting yeast cells in an enzyme-catalyzed intracellular reaction, are responsible for the fruity character of fermented alcoholic beverages such as Chinese yellow rice wine. Alcohol acetyltransferase (AATase) is currently believed to be the key enzyme responsible for the production of acetate ester.

Critical evaluation of transcription factor Atf2 as a candidate modulator of alcohol preference in mouse and human populations

L. S. Wang, Jiao, Y., Huang, Y., Liu, X. Y., Gibson, G., Bennett, B., Hamre, K. M., Li, D. W., Zhao, H. Y., Gelernter, J., Kranzler, H. R., Farrer, L. A., Lu, L., Wang, Y. J., and Gu, W. K., Critical evaluation of transcription factor Atf2 as a candidate modulator of alcohol preference in mouse and human populations, vol. 12, pp. 5992-6005, 2013.

In prior work, congenic strains carrying the DBA/2Igb (D2) region of chromosome 2 (Chr2) for alcohol preference were bred onto a C57BL/6Ibg (B6) background and as predicted were found to reduce voluntary consumption. Subsequently, interval-specific congenic recombinant strains (ISCRS) were generated and also tested. These ISCRS strains reduced the quantitative trait loci (QTL) interval to a comparatively small 3.4 Mb region. Here, we have exploited an integrative approach using both murine and human populations to critically evaluate candidate genes within this region.

Subscribe to Atf2