BACE1

Effect of the beta secretase-1 inhibitor on the amyloid C-terminal fragment of amyloid precursor protein processing in a hyperphosphorylated tau rat model

H. Y. Chen, Wang, L., Liu, J. F., Wang, W. Z., and Yu, C. J., Effect of the beta secretase-1 inhibitor on the amyloid C-terminal fragment of amyloid precursor protein processing in a hyperphosphorylated tau rat model, vol. 13, pp. 6213-6227, 2014.

The amyloid C-terminal fragment (βCTF) of the amyloid precursor protein (APP) is the cleaved component of APP by beta secretase-1 (BACE1), which shows similar neurotoxicity as amyloid beta (Aβ) in many ways. Evidence suggested that in addition to Aβ, βCTF might also participate in the pathogenesis of Alzheimer’s disease (AD). In recent years, the relationship between βCTF processing and hyperphosphorylated tau has attracted increasing research attention.

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