Balanced translocation

Male carriers of balanced reciprocal translocations in Northeast China: sperm count, reproductive performance, and genetic counseling

H. G. Zhang, Wang, R. X., Li, L. L., Sun, W. T., Zhang, H. Y., and Liu, R. Z., Male carriers of balanced reciprocal translocations in Northeast China: sperm count, reproductive performance, and genetic counseling, vol. 14, pp. 18792-18798, 2015.

Balanced chromosomal translocations in men can cause failure of spermatogenesis owing to meiotic impairment. Male carriers may exhibit normozoospermia, although clinical manifestations can include oligozoospermia or azoospermia, oligozoospermia or normozoospermia. Here, we reported the characteristics of balanced reciprocal translocations in men from northeastern China, and explored the relationship between sperm count and reproductive performance, to enable informed genetic counseling. The frequency of balanced reciprocal translocations was found to be 1.62%.

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