Berberine

Inhibitory effect of berberine on human skin squamous cell carcinoma A431 cells

D. X. Li, Zhang, J., Zhang, Y., Zhao, P. W., and Yang, L. M., Inhibitory effect of berberine on human skin squamous cell carcinoma A431 cells, vol. 14, pp. 10553-10568, 2015.

Berberine (BBR) is a natural alkaloid with significant anti-tumor activity against many types of cancer cells. In this study, we investigated the molecular mechanisms employed by BBR to repress the proliferation and growth of skin squamous cell carcinoma A431 cells.

Glucagon-induced angiogenesis and tumor growth through the HIF-1-VEGF-dependent pathway in hyperglycemic nude mice

Y. Wang, Zhu, Y. D., Gui, Q., Wang, X. D., and Zhu, Y. X., Glucagon-induced angiogenesis and tumor growth through the HIF-1-VEGF-dependent pathway in hyperglycemic nude mice, vol. 13, pp. 7173-7183, 2014.

In this study, we examined the effect glucagon-induced hyperglycemia on tumor growth as well as the role of the hypoxia-inducible factor 1 (HIF-1)-vascular endothelial growth factor (VEGF) pathway in this condition. A high concentration of glucose (HG) was utilized to treat HeLa cells under hypoxic or normoxic conditions, and transcriptional levels of HIF-1, VEGF, and basic fibroblast growth factor (bFGF) were evaluated. Moreover, the ability of an HIF-1 inhibitor to block the effect induced by HG was examined.

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