Beta-casein locus

Targeting exogenous GDNF gene to the bovine somatic cell beta-casein locus for the production of transgenic bovine animals

X. M. Zhang, Luo, F. H., Ding, H. M., Li, B., Zhang, J. J., and Wu, Y. J., Targeting exogenous GDNF gene to the bovine somatic cell beta-casein locus for the production of transgenic bovine animals, vol. 14, pp. 14989-14998, 2015.

Considerable attention is currently being directed toward methods for producing recombinant human proteins in the mammary glands of genetically modified transgenic livestock. However, the expression of inserted genes in transgenic animals is variable and often very low because of the randomness of the site of transgene integration. One possible strategy to avoid the expression problem associated with random integration is to use site-specific integration by targeting integration to a high expression locus and, thereby, to improve expression of the transferred gene.

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