Bioequivalence

Bioequivalence of clopidogrel hydrogen sulfate tablets in healthy Chinese volunteers

Y. G. Yang, Zhang, M., Jiang, N., Song, L. X., Xu, X. T., Di, X. H., Xu, L., Xu, J., and Zhao, G. T., Bioequivalence of clopidogrel hydrogen sulfate tablets in healthy Chinese volunteers, vol. 14, pp. 16736-16743, 2015.

We aimed to evaluate the bioequivalence of clopidogrel in healthy Chinese volunteers after administration of a single oral dose. We administered a single oral dose of 75 mg clopidogrel (test and reference) to 32 healthy Chinese volunteers according to an open, randomized, crossover design. The concentration of clopidogrel acid (carboxylic metabolite of clopidogrel) in the plasma was determined using liquid chromatography-tandem mass spectrometry (LC-MS/MS).

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