Bladder cancer

Chemokine receptor CXCR4 and its ligand CXCL12 expressions and clinical significance in bladder cancer

D. L. Yang, Xin, M. M., Wang, J. S., Xu, H. Y., Huo, Q., Tang, Z. R., and Wang, H. F., Chemokine receptor CXCR4 and its ligand CXCL12 expressions and clinical significance in bladder cancer, vol. 14, pp. 17699-17707, 2015.

It is well known that chemokine receptors and their ligands play important roles in mediating the invasion and metastasis of malignant tumors. This aim of this study was to investigate the expression and clinical significance of chemokine receptor CXCR4 and its ligand CXCL12 in bladder tumor tissues. Cancerous and adjacent normal bladder tissues were collected from 42 patients. The expressions of CXCR4 and CXCL12 proteins were then detected by immunohistochemistry, and the expressions of CXCR4 and CXCL12 mRNAs were detected by RT-PCR.

Serum Dickkopf-1 levels as a clinical and prognostic factor in patients with bladder cancer

D. K. Sun, Wang, L., Wang, J. M., and Zhang, P., Serum Dickkopf-1 levels as a clinical and prognostic factor in patients with bladder cancer, vol. 14, pp. 18181-18187, 2015.

Dickkopf-1 (DKK-1) is a secreted protein that inhibits Wnt signaling. However, the clinical significance and prognostic value of serum DKK-1 levels have not been previously investigated in bladder cancer in Chinese patients. Blood samples were taken from 94 consecutive patients diagnosed with bladder cancer and 60 healthy control subjects. Serum DKK-1 expression levels were measured by enzyme-linked immunosorbent assay according to the manufacturer’s directions.

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