Bladder cancer

Association between MYC rs9642880[T] allele and bladder cancer risk: a meta-analysis

Y. Zhao, Qi, J. G., Yang, N., Lin, Y. L., Liang, J., and Zhu, X., Association between MYC rs9642880[T] allele and bladder cancer risk: a meta-analysis, vol. 14, pp. 14745-14751, 2015.

A single nucleotide polymorphism of MYC rs9642880 (G>T) at the 8q24.1 locus is thought to be associated with bladder cancer risk based on the results of genome-wide association studies, but the results remain inconclusive. To assess the association between rs9642880[T] allele and bladder cancer risk, we performed this meta-analysis including 18 case-control studies and involving 23,084 cases and 97,164 controls. Electronic searches for publications were conducted to determine the association between this variant and prostate cancer in several databases.

729G/C polymorphism in Toll-like receptor 4 results in increased susceptibility to bladder cancer

B. Wan, Tan, J., Zeng, Q., He, L. Y., Gan, Y., Dai, Y. B., and Yao, K., 729G/C polymorphism in Toll-like receptor 4 results in increased susceptibility to bladder cancer, vol. 14, pp. 15482-15487, 2015.

In this study, the association between the 729G/C polymorphism in Toll-like receptor 4 (TLR4) and the risk of bladder cancer was investigated. A total of 376 patients with bladder cancer and 380 healthy volunteers from the Third Xiangya Hospital of Central South University (China) were enrolled in this study between January 2008 and February 2014. The TLR4-729G/C polymorphism was detected by the polymerase chain reaction-restriction fragment length polymorphism assay.

Prognostic role of microRNA-100 in patients with bladder cancer

Y. H. Cao, Zhang, H. H., Xu, H. F., Duan, Y. J., Li, Q., and Huang, B., Prognostic role of microRNA-100 in patients with bladder cancer, vol. 14, pp. 15948-15954, 2015.

We investigated the clinical significance and prognostic value of microRNA-100 (miR-100) in bladder cancer. Quantitative real-time polymerase chain reaction was used to analyze the expression of miR-100 in 92 pairs of human bladder cancer and adjacent normal tissue samples. Overall survival (OS) curves were plotted using the Kaplan-Meier method and were evaluated for statistical significance using a log-rank test. The significance of different variables with respect to survival was analyzed using the multivariate Cox proportional hazard model.

Meta-analysis of the relationship between slow acetylation of N-acetyl transferase 2 and the risk of bladder cancer

Y. An, Li, H., Wang, K. J., Liu, X. H., Qiu, M. X., Liao, Y., Huang, J. L., and Wang, X. S., Meta-analysis of the relationship between slow acetylation of N-acetyl transferase 2 and the risk of bladder cancer, vol. 14, pp. 16896-16904, 2015.

The incidence of bladder cancer is closely associated with exposure to aromatic amines, that can cause cancer only after metabolic activation regulated by N-acetyl transferase 1 and 2 (NAT1 and NAT2). Many studies have indicated that slow acetylation of NAT2 increases the risk of bladder cancer. The major risk factor is tobacco smoke; however, some studies have failed to prove this. This study attempted to explore the correlation between NAT2 slow acetylation and bladder cancer risk through a meta-analysis of published case-control studies.

Subscribe to Bladder cancer