Blastic crisis

Discovery of somatic mutations in the progression of chronic myeloid leukemia by whole-exome sequencing

Y. Huang, Zheng, J., Hu, J. D., Wu, Y. A., Zheng, X. Y., Liu, T. B., and Chen, F. L., Discovery of somatic mutations in the progression of chronic myeloid leukemia by whole-exome sequencing, vol. 13, pp. 945-953, 2014.

We performed whole-exome sequencing in samples representing accelerated phase (AP) and blastic crisis (BC) in a subject with chronic myeloid leukemia (CML). A total of 12.74 Gb clean data were generated, achieving a mean depth coverage of 64.45 and 69.53 for AP and BC samples, respectively, of the target region. A total of 148 somatic variants were detected, including 76 insertions and deletions (indels), 64 single-nucleotide variations (SNV), and 8 structural variations (SV).

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