Bleomycin

Atomized paclitaxel liposome inhalation treatment of bleomycin-induced pulmonary fibrosis in rats

Y. Zhou, Zhu, W. P., Cai, X. J., Chen, M., Zhou, Y., Zhu, W. P., Cai, X. J., Chen, M., Zhou, Y., Zhu, W. P., Cai, X. J., and Chen, M., Atomized paclitaxel liposome inhalation treatment of bleomycin-induced pulmonary fibrosis in rats, vol. 15, p. -, 2016.

We sought to determine the efficacy of atomized paclitaxel liposome inhalation treatment of pulmonary fibrosis in a bleomycin-induced rat model. Forty male Sprague-Dawley rats were randomly divided into four groups: healthy control, pulmonary fibrosis without treatment, paclitaxel liposome inhalation-treated, and intravenous paclitaxel liposome-treated. Fibrosis was induced by bleomycin injection. A total of 20 mg/kg paclitaxel liposome was administered by inhalation every other day for a total of 10 doses.

Toll-like receptor 4 promotes fibrosis in bleomycin-induced lung injury in mice

X. X. Li, Jiang, D. Y., Huang, X. X., Guo, S. L., Yuan, W., and Dai, H. P., Toll-like receptor 4 promotes fibrosis in bleomycin-induced lung injury in mice, vol. 14, pp. 17391-17398, 2015.

The specific role of Toll-like receptor 4 (TLR4) in bleomycin-induced lung fibrosis of mice, a model of human idiopathic pulmonary fibrosis, has not been characterized. We injected bleomycin intratracheally into TLR4 knockout (TLR4-/-) and wild-type (WT) mice. Twenty-one days after injection, mice were sacrificed and their lungs were harvested for pathological, hydroxyproline, mRNA expression, and collagen I analyses. Body weight changes and mortality were observed.

Subscribe to Bleomycin