Bone morphogenetic protein 2

BMP-2 promotes chondrogenesis of rat adipose-derived stem cells by using a lentiviral system

H. L. Fu, Diao, Z. Y., Shao, L., and Yang, D. P., BMP-2 promotes chondrogenesis of rat adipose-derived stem cells by using a lentiviral system, vol. 13, pp. 8620-8631, 2014.

Osteoporosis poses a major public health threat in aging societies. Adipose-derived stem cells (ADSCs) are multipotent adult stem cells that have the ability to yield mesenchymal stem cells, and have the potential to undergo osteogenesis and bone regeneration. Bone morphogenetic proteins (BMPs) have been demonstrated to upregulate bone gene expression after mechanical injury and to improve bone injury repair. This study aimed to produce BMP-2 expression in ADSCs by using lentiviral vectors. Subcutaneous adipose tissue from 4-week-old male Sprague-Dawley rats was used.

Phenotype characterization and sequence analysis of BMP2 and BMP4 variants in two Mexican families with oligodontia

Y. Mu, Xu, Z., Contreras, C. I., McDaniel, J. S., Donly, K. J., and Chen, S., Phenotype characterization and sequence analysis of BMP2 and BMP4 variants in two Mexican families with oligodontia, vol. 11, pp. 4110-4120, 2012.

Both BMP2 and BMP4 are involved in tooth development. We examined phenotypes and BMP2 and BMP4 gene variations in two Mexican oligodontia families. Physical and oral examinations and panoramic radiographs were performed on affected and unaffected members in these two families. The affected members lacked six or more teeth. DNA sequencing was performed to detect BMP2 and BMP4 gene variations.

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