BRCA2

Association of BRCA2 variants with cardiovascular disease in Saudi Arabia

M. Alanazi, Reddy, N. P., Shaik, J. P., Ajaj, S. A., Jafari, A. A. A., Saeed, H., Khan, Z., and Khan, A. P., Association of BRCA2 variants with cardiovascular disease in Saudi Arabia, vol. 13, pp. 3876-3884, 2014.

Abnormalities in the breast cancer tumor suppressor genes (BRCA1 and BRCA2) are associated with breast and ovarian cancer. Recently, two single nucleotide polymorphisms (SNPs; rs11571836 and rs1799943) were identified, both located in untranslated regions of chromosome 13, associated with cardiovascular disease (CVD) in a multi-ethnic population. We examined the association between these BRCA2 polymorphisms and traits of CVD patients from Saudi Arabia. We genotyped rs11571836 and rs1799943 in 159 unrelated CVD patients and 176 healthy controls.

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