Breast cancer

Clinical applications of internal heat source analysis for breast cancer identification

F. Han, Liang, C. W., Shi, G. L., Wang, L., and Li, K. Y., “Clinical applications of internal heat source analysis for breast cancer identification”, vol. 14, pp. 1450-1460, 2015.

Nondestructive preoperative breast imaging techniques are widely used for breast cancer testing and diagnosis. This study aimed to evaluate the feasibility and efficacy of quantitative diagnosis via the thermal analysis of abnormal metabolism. Nine hundred forty-eight women who underwent breast biopsy from 2009 to 2013 were investigated. Thermal analysis was used to calculate the internal heat source (i.e., tumor) thermal power for each participant.

1236 C/T and 3435 C/T polymorphisms of the ABCB1 gene in Mexican breast cancer patients

S. A. Gutiérrez-Rubio, Quintero-Ramos, A., Durán-Cárdenas, A., Franco-Topete, R. A., Castro-Cervantes, J. M., Oceguera-Villanueva, A., Jiménez-Pérez, L. M., Balderas-Peña, L. M. A., Morgan-Villela, G., Del-Toro-Arreola, A., and Daneri-Navarro, A., “1236 C/T and 3435 C/T polymorphisms of the ABCB1 gene in Mexican breast cancer patients”, vol. 14, pp. 1250-1259, 2015.

MDR1, which is encoded by the ABCB1 gene, is involved in multidrug resistance (hydrophobic), as well as the elimination of xenotoxic agents. The association between ABCB1 gene polymorphisms and breast cancer risk in different populations has been described previously; however, the results have been inconclusive. In this study, we examined the association between polymorphisms 3435 C/T and 1236 C/T in the ABCB1 gene and breast cancer development in Mexican women according to their menopausal status and molecular classification.

Effects of Herceptin on circulating tumor cells in HER2 positive early breast cancer

J. - L. Zhang, Yao, Q., Chen, J. - H., Wang, Y., Wang, H., Fan, Q., Ling, R., Yi, J., and Wang, L., “Effects of Herceptin on circulating tumor cells in HER2 positive early breast cancer”, vol. 14, pp. 2099-2103, 2015.

The objective of this study was to determine the changes in peripheral blood circulating tumor cells in HER2-positive early breast cancer before and after Herceptin therapy, and to explore the effects of the HER2 gene and Herceptin on circulating tumor cells. CK19 mRNA expression in peripheral blood was evaluated by qRT-PCR as an index of circulating tumor cells in 15 cases of HER-2-positive breast cancer and 18 cases of HER2-negative breast cancer before, and after chemotherapy as well.

TCF7L2 gene polymorphisms and susceptibility to breast cancer: a meta-analysis

X. P. Lu, Hu, G. N., Du, J. Q., and Li, H. Q., “TCF7L2 gene polymorphisms and susceptibility to breast cancer: a meta-analysis”, vol. 14, pp. 2860-2867, 2015.

Numerous studies have evaluated the association between TCF7L2 gene polymorphisms (rs12255372 and rs7903146) and breast cancer risk. However, the results have been inconsistent. Therefore, in the current study, we performed a meta-analysis. A systematically literature search of the PubMed and EMBASE databases was conducted in November 2013, and the reference lists of articles were retrieved. A summary odds ratio (OR) with its 95% confidence interval (CI) were calculated to evaluate the strength of association. Publication bias was investigated using Begg’s funnel plot.

Expression and significance of SATB1 in the development of breast cancer

S. Zhang, Gao, X., Ma, Y., Jiang, J., Dai, Z., Yin, X., Min, W., Hui, W., and Wang, B., “Expression and significance of SATB1 in the development of breast cancer”, vol. 14, pp. 3309-3317, 2015.

Special AT-rich sequence binding protein 1 (SATB1) is a recently discovered gene regulator that can promote the growth and metastasis of breast cancer. However, its expression in different stages of breast cancer development have not been examined. We explored the role of SATB1 in the development of breast cancer by detecting SATB1 expression levels in different stages of breast cancer.

Association of the C677T polymorphism in the methylenetetrahydrofolate reductase gene with breast cancer in a Mexican population

A. Ramos-Silva, Figuera, L. E., Soto-Quintana, O. M., Puebla-Pérez, A. M., Ramírez-Patiño, R., Gutiérrez-Hurtado, I., Carrillo-Moreno, D. I., Zúñiga-González, G. M., Dávalos-Rodríguez, I. P., and Gallegos-Arreola, M. P., “Association of the C677T polymorphism in the methylenetetrahydrofolate reductase gene with breast cancer in a Mexican population”, vol. 14, pp. 4015-4026, 2015.

The methylenetetrahydrofolate reductase (MTHFR) gene plays an important role in the steps involved in the processing of amino acids. The analysis of polymorphisms in the MTHFR gene has revealed associations with cancer; in particular the C677T polymorphism, which has been suggested to affect folate metabolism, DNA methylation, synthesis, and repair, and to contribute to tumor promotion in the mammary gland.

Effects of the Zhikang capsule on healing of the flap after radical breast cancer surgery

C. Cheng, Lv, Y., Zhang, E., Yan, T., Li, C., Hou, D. - X., and Li, J. - H., “Effects of the Zhikang capsule on healing of the flap after radical breast cancer surgery”, vol. 14, pp. 5127-5131, 2015.

This study aimed to investigate the effect and mechanism of trauma flap healing promoted by the Zhikang capsule after radical breast cancer surgery. The enrolled breast cancer patients were randomly divided into two groups: treatment and observation. The patients in the treatment group were treated with the Zhikang capsule in addition to the conventional dressing changes, while patients in the observation group underwent only the regular dressing changes.

PUMA gene transfection can enhance the sensitivity of epirubicin-induced apoptosis of MCF-7 breast cancer cells

C. - G. Sun, Zhuang, J., Teng, W. - J., Wang, Z., and Du, S. - S., “PUMA gene transfection can enhance the sensitivity of epirubicin-induced apoptosis of MCF-7 breast cancer cells”, vol. 14, pp. 5742-5749, 2015.

We explored whether p53 upregulated modulator of apoptosis (PUMA) gene transfection could enhance the sensitivity of epirubicin-induced apoptosis of MCF-7 breast cancer cells. The liposome-mediated recombinant eukaryotic expression vector PU­MA-pCDNA3 and empty vector plasmid were stably transfected into MCF-7 cells. Epirubicin (0.01-100 μM) was applied to MCF-7, MCF-7/PUMA, and MCF-7/pCDNA3 cells for 72 h. The MTT assay was used to calculate the cell survival rate in each group, and the 50% in­hibitory concentration (IC50) was calculated.

Associations of miRNA polymorphisms and expression levels with breast cancer risk in the Chinese population

P. Qi, Wang, L., Zhou, B., Yao, W. J., Xu, S., Zhou, Y., and Xie, Z. B., “Associations of miRNA polymorphisms and expression levels with breast cancer risk in the Chinese population”, vol. 14, pp. 6289-6296, 2015.

Single-nucleotide polymorphisms in microRNAs (miRNAs) may dramatically affect gene expression and subsequently alter individual susceptibility to cancer, and thus has become a research hotspot for many cancer types, including breast cancer. We recruited 321 breast cancer patients and 290 controls in our study. Four established miRNA single-nucleotide polymorphisms (mir-499 rs3746444 A>G; miR-27a rs895819 A>G; miR-196a2 rs11614913 T>C; miR-146a rs2910164 G/C) were detected using Taqman assays.

Polymorphisms in GSTM1, GSTT1, GSTP1, and GSTM3 genes and breast cancer risk in northeastern Mexico

G. Jaramillo-Rangel, Ortega-Martínez, M., Cerda-Flores, R. M., and Barrera-Saldaña, H. A., “Polymorphisms in GSTM1, GSTT1, GSTP1, and GSTM3 genes and breast cancer risk in northeastern Mexico”, vol. 14. pp. 6465-6471, 2015.

Glutathione S-transferases (GSTs) are a family of phase II metabolizing enzymes involved in carcinogen detoxification and the metabolism of various bioactive compounds. Several genes that code for these enzymes are polymorphic in an ethnicity-dependent manner, with particular genotypes previously associated with an increased risk of breast cancer.

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