Breast cancer

Analysis of polymorphisms in codons 11, 72 and 248 of TP53 in Brazilian women with breast cancer

B. C. Almeida, Kleine, J. P. F. O., Camargo-Kosugi, C. M., Lisboa, M. R., França, C. N., França, J. P., Silva, I. D. C. G., Almeida, B. C., Kleine, J. P. F. O., Camargo-Kosugi, C. M., Lisboa, M. R., França, C. N., França, J. P., and Silva, I. D. C. G., Analysis of polymorphisms in codons 11, 72 and 248 of TP53 in Brazilian women with breast cancer, vol. 15, p. -, 2016.

The association between TP53 gene polymorphisms and breast cancer (BC) in Brazilian women is a controversial topic. In this cross-sectional study, we evaluated the association between clinical pathological variables and three polymorphisms (TP53*11, TP53*72, and TP53*248) in BC patients and controls. Genomic DNA was extracted from the blood cells of 393 participants; the cancer-free control subjects were 26-72 years old (41 ± 11.03) and the BC patients were 28-80 years old (51 ± 10.70).

Polymorphisms in promoter regions of IL-6 and IL-10 genes in breast cancer: a case-control study

E. S. AlSuhaibani, Kizilbash, N. A., Malik, S., Dasti, J. I., F. Beladi, A., El-Morshedi, N., AlSuhaibani, E. S., Kizilbash, N. A., Malik, S., Dasti, J. I., F. Beladi, A., El-Morshedi, N., AlSuhaibani, E. S., Kizilbash, N. A., Malik, S., Dasti, J. I., F. Beladi, A., and El-Morshedi, N., Polymorphisms in promoter regions of IL-6 and IL-10 genes in breast cancer: a case-control study, vol. 15, p. -, 2016.

Polymorphisms in interleukin genes (IL-6 and IL-10) are involved in the pathogenesis of breast cancer. This study investigated polymorphisms in the promoter regions of IL-6 (-174G/C) and IL-10 (-1082G/A) through a case-control study employing 80 female subjects who were pathologically diagnosed with breast cancer. All patients received follow-up care at the Mansoura University Hospital, Mansoura, Egypt. We included another 80 females (controls) from the same population, showing no signs of malignancy.

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