Breast cancer

Gly71Arg UGT1A1 polymorphism is associated with breast cancer susceptibility in Han Chinese women

J. Shi, Li, L. H., Duan, X. Y., Liu, Q., Sun, L. L., Tian, Y. T., Shi, J., Li, L. H., Duan, X. Y., Liu, Q., Sun, L. L., and Tian, Y. T., Gly71Arg UGT1A1 polymorphism is associated with breast cancer susceptibility in Han Chinese women, vol. 15, p. -, 2016.

Breast cancer is among the most common causes of cancer-related death in women worldwide. Previous studies have demonstrated an association between prolonged estrogen exposure and increased risk of breast cancer. Uridine 5'-diphospho-glucuronosyltransferase 1-1 (UGT1A1) plays a significant role in the detoxification of estrogens. Two major genetic polymorphisms have been identified in the UGT1A1 locus. UGT1A1*28 has been previously linked to increased risk of breast cancer.

Low levels of serum miR-99a is a predictor of poor prognosis in breast cancer

J. Li, Song, Z. J., Wang, Y. Y., Yin, Y., Liu, Y., Nan, X., Li, J., Song, Z. J., Wang, Y. Y., Yin, Y., Liu, Y., and Nan, X., Low levels of serum miR-99a is a predictor of poor prognosis in breast cancer, vol. 15, p. -, 2016.

MicroRNA (miRNA) deregulation has been previously linked to the initiation and development of breast cancer. Although miR-99a is aberrantly expressed in many types of cancers, including breast cancer, the serum miR-99a expression level in breast cancer and its clinical significance remains unknown. Blood samples were obtained from 72 patients with breast cancer and 40 healthy volunteers, and subjected to real-time polymerase chain reaction to evaluate the level of expression of serum miR-99a in the study participants.

Correlation between serum level of chemokine (C-C motif) ligand 18 and poor prognosis in breast cancer

J. H. Sun, Fan, N., Zhang, Y., Sun, J. H., Fan, N., and Zhang, Y., Correlation between serum level of chemokine (C-C motif) ligand 18 and poor prognosis in breast cancer, vol. 15, p. -, 2016.

In this study, we investigated the correlation between serum chemokine (C-C motif) ligand 18 (CCL-18) and the prognosis as well as clinical characteristics of breast cancer. Blood samples from 207 breast cancer patients, 126 individuals with benign breast tumors, and 93 healthy women were collected. Serum CCL-18 expression was detected by enzyme-linked immunosorbent assay. Mann-Whitney’s U tests were carried out to analyze the relationship between serum CCL-18 and clinicopathological variables.

Relationship between genetic polymorphisms of methylenetetrahydrofolate reductase and breast cancer chemotherapy response

L. Yang, Wang, X. W., Zhu, L. P., Wang, H. L., Wang, B., Wu, T., Zhao, Q., JinSiHan, D. L. X. T., Wang, X. Y., Yang, L., Wang, X. W., Zhu, L. P., Wang, H. L., Wang, B., Wu, T., Zhao, Q., JinSiHan, D. L. X. T., and Wang, X. Y., Relationship between genetic polymorphisms of methylenetetrahydrofolate reductase and breast cancer chemotherapy response, vol. 15, p. -, 2016.

Activity of methylenetetrahydrofolate reductase (MTHFR), an enzyme involved in folate metabolism, is influenced by mutations in the corresponding gene, contributing to a decrease in 5,10-MTHF. Due to such polymorphisms, individuals differ in MTHFR enzyme activity and plasma folate levels. We investigated the relationship between two common MTHFR polymorphisms (C677T and A1298C) and breast cancer (BC) chemotherapy response.

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