Breast cancer

A functional insertion/deletion polymorphism in the IL1A gene is associated with decreased risk of breast cancer

X. Huang, Yang, Y., Cui, Z. W., Wang, J., Gao, L. B., Huang, X., Yang, Y., Cui, Z. W., Wang, J., and Gao, L. B., A functional insertion/deletion polymorphism in the IL1A gene is associated with decreased risk of breast cancer, vol. 15, p. -, 2016.

The insertion/deletion polymorphism (rs3783553 TTCA/-) in the 3' untranslated region of interleukin-1A (IL1A) has been studied intensively and has been shown to affect tumor risk. We studied the frequency of the IL1A gene polymorphism rs3783553 and evaluated its relationship with breast cancer (BC). A hospital-based case-control study comprising 228 patients with histologically confirmed BC and 241 healthy subjects was conducted. Polymerase chain reaction was used to detect the IL1A rs3783553 polymorphism.

Relationship between SPOP mutation and breast cancer in Chinese population

M. A. Khan, Zhu, L., Tania, M., Xiao, X. L., and Fu, J. J., Relationship between SPOP mutation and breast cancer in Chinese population, vol. 14, pp. 12362-12366, 2015.

SPOP protein has been found to have ubiquitin ligase activity. Mutations in SPOP gene have been recently reported in some cancers such as prostate, gastric, colorectal cancer. We investigated SPOP DNA mutation in tumor tissues collected from 70 Chinese female breast cancer patients in Southwestern China by DNA sequencing. The results did not show mutation in our tissue samples, indicating that a mutation in the SPOP gene may not be associated with breast cancer, particularly in Chinese women.

Association of the GSTM1 null polymorphism with breast cancer in a Mexican population

O. Soto-Quintana, Zúñiga-González, G. M., Ramírez-Patiño, R., Ramos-Silva, A., Figuera, L. E., Carrillo-Moreno, D. I., Gutiérrez-Hurtado, I. A., Puebla-Pérez, A. M., Sánchez-Llamas, B., and Gallegos-Arreola, M. P., Association of the GSTM1 null polymorphism with breast cancer in a Mexican population, vol. 14, pp. 13066-13075, 2015.

The glutathione S transferase (GST) family plays an important role in the processing of carcinogens. Data on the null GSTM1 genotype has revealed associations with cancer, and has been suggested to affect carcinogen metabolism and to contribute to tumor promotion in the mammary gland. We examined the role of the null GSTM1 genotype by comparing the genotypes of 276 healthy Mexican women with those of 558 Mexican women with breast cancer (BC).

Mutational analysis of BRCA1/2 gene and pathologic characteristics from Kazakh population with sporadic breast cancer in northwestern China

S. Y. Yang, Aisimutula, D., Li, H. F., Hu, Y., Du, X., Li, J., and Luan, M. X., Mutational analysis of BRCA1/2 gene and pathologic characteristics from Kazakh population with sporadic breast cancer in northwestern China, vol. 14, pp. 13151-13161, 2015.

Mutations in the BRCA1/2 genes are associated with an increased risk of breast cancer, but no large-scale research have examined the BRCA1/2 mutations in Chinese Kazakh women. We evaluated the frequency and distributions of BRCA1 and BRCA2 gene mutations in Kazakh sporadic breast cancer patients and healthy women in China. The association between the clinical-pathologic features of Kazakh breast cancer patients and BRCA1/2 mutations were also investigated.

Angiotensin II type 1 receptor gene A1166C polymorphism and breast cancer susceptibility

L. Li, Wang, F., Lv, P. W., Zhu, M. Z., He, J. J., Guo, G. C., Gu, Y. T., and Han, M. L., Angiotensin II type 1 receptor gene A1166C polymorphism and breast cancer susceptibility, vol. 14, pp. 15016-15023, 2015.

Numerous studies have evaluated the association between the angiotensin II type-1 receptor (AGTR1) gene A1166C polymorphism and breast cancer risk. However, the specific association is controversial. The aim of the present study was to derive a more precise estimation of the relationship. A comprehensive research was conducted of the PubMed and the Google Scholar databases through February 2015. Data were assessed using STATA version 12.0. Pooled odds ratios with 95%CIs were derived from the fixed-effect or random-effect models.

Study of PIK3CA, BRAF, and KRAS mutations in breast carcinomas among Chinese women in Qinghai

Y. L. Wang, Dai, X., Li, Y. D., Cheng, R. X., Deng, B., Geng, X. X., and Zhang, H. J., Study of PIK3CA, BRAF, and KRAS mutations in breast carcinomas among Chinese women in Qinghai, vol. 14, pp. 14840-14846, 2015.

Phosphatidylinositol-3-OH kinase and RAS-activated signaling pathways play an important role in tumor formation. Abnormalities in relevant genes play essential roles in the occurrence and development of many human cancers. Studies of breast cancer have mainly focused on the women in western countries, but few studies have examined the frequency of mutations in PIK3CA, BRAF, and KRAS in Chinese breast cancer patients.

Association between MTHFR 677C/T and 1298A/C gene polymorphisms and breast cancer risk

X. F. Zhang, Liu, T., Li, Y., and Li, S., Association between MTHFR 677C/T and 1298A/C gene polymorphisms and breast cancer risk, vol. 14, pp. 16425-16430, 2015.

We performed a case-control study to investigate the association between single nucleotide polymorphisms in the MTHFR gene (677C/T and 1298A/C) and risk of breast cancer. This case-control study included 216 breast cancer cases and 216 controls. The MTHFR 677C/T and 1298A/C gene polymorphisms were assessed by polymerase chain reaction restriction fragment length polymorphism.

Lack of association between the aryl hydrocarbon receptor rs2066853 polymorphism and breast cancer: A meta-analysis on Ahr polymorphism and breast cancer

Y. Li, Qin, H. Z., Song, Q., Wu, X. D., and Zhu, J. H., Lack of association between the aryl hydrocarbon receptor rs2066853 polymorphism and breast cancer: A meta-analysis on Ahr polymorphism and breast cancer, vol. 14, pp. 16162-16168, 2015.

Published data regarding the association between aryl hydrocarbon receptor (Ahr) rs2066853 polymorphism and the risk of breast cancer shows conflicting results. We performed a meta-analysis on 2999 patients and 3050 controls from three related case-control studies to estimate the association between Ahr rs2066853 polymorphism and the risk of breast cancer. The protocol was approved by the Institutional Animal Care and Use Committee (IACUC) at the University of Florida (America NIH Publication No. 86-231985 Revision).

Association of a let-7 KRAS rs712 polymorphism with the risk of breast cancer

X. Huang, Yang, Y., Guo, Y., Cao, Z. L., Cui, Z. W., Hu, T. C., and Gao, L. B., Association of a let-7 KRAS rs712 polymorphism with the risk of breast cancer, vol. 14, pp. 16913-16920, 2015.

Breast cancer (BC) is a common malignancy affecting women, with increasing incidences of this disease in China every year. Recent studies have extensively investigated a single nucleotide polymorphism in the let-7 miRNA binding site of the 3'-untranslated region of KRAS mRNA. The aim of this study was to determine the genotype frequency of the KRAS rs712 polymorphism, and evaluate its effect on BC risk. This hospital-based case-control study comprised 228 patients with histologically confirmed BC and 251 healthy controls.

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