Breast cancer

Screening for key genes associated with invasive ductal carcinoma of the breast via microarray data analysis

J. L. Huan, Gao, X., Xing, L., Qin, X. J., Qian, H. X., Zhou, Q., and Zhu, L., Screening for key genes associated with invasive ductal carcinoma of the breast via microarray data analysis, vol. 13, pp. 7919-7925, 2014.

The aim of this study was to identify key genes related to invasive ductal carcinoma (IDC) of the breast by analyzing gene expression data with bioinformatic tools. Microarray data set GSE31138 was downloaded from Gene Expression Omnibus, including 3 breast cancer tissue samples and 3 normal controls. Differentially expressed genes (DEGs) between breast cancer and normal control were screened out (FDR 2). Coexpression between genes was examined with String, and a network was then constructed. Relevant pathways and diseases were retrieved with KOBAS.

Association between polymorphisms in the thymidylate synthase gene and risk of breast cancer in a Mexican population

A. Quintero-Ramos, Gutiérrez-Rubio, S. A., Del Toro-Arreola, A., Franco-Topete, R. A., Oceguera-Villanueva, A., Jiménez-Pérez, L. M., Castro-Cervantes, J. M., Barragán-Ruiz, A., Vázquez-Camacho, J. G., and Daneri-Navarro, A., Association between polymorphisms in the thymidylate synthase gene and risk of breast cancer in a Mexican population, vol. 13, pp. 8749-8756, 2014.

Breast cancer (BC) is the leading cause of cancer-related deaths among women in Mexico. Two single-nucleotide polymorphisms (SNPs) in the thymidylate synthase (TS) gene, the 28-base pair (bp) tandem repeat in the TS 5'-untranslated enhanced region (TSER) and the 6-bp insertion/deletion in the TS 3'-untranslated region (TS 3'-UTR), increase the rate of misincorporation of uridylate into DNA and may lead to chromosomal damage. We examined the association between these polymorphisms and BC risk in Mexican women according to menopause status.

Association between dietary intake of folate and MTHFR and MTR genotype with risk of breast cancer

J. M. He, Pu, Y. D., Wu, Y. J., Qin, R., Zhang, Q. J., Sun, Y. S., Zheng, W. W., and Chen, L. P., Association between dietary intake of folate and MTHFR and MTR genotype with risk of breast cancer, vol. 13, pp. 8925-8931, 2014.

We investigated the association between dietary intake of folate, vitamin B6, and the 5,10-methylenetetrahydrofolate reductase (MTHFR) genotype with breast cancer. A matched case-control study was conducted, and 413 patients with newly diagnosed and histologically confirmed breast cancer and 436 controls were recruited. Folate intake, vitamin B6, and vitamin B12 levels were calculated, and the MTHFR C677T and A1298C and MTR A2756G polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism.

Anatomical information for intercostobrachial nerve preservation in axillary lymph node dissection for breast cancer

J. J. Zhu, Liu, X. F., Zhang, P. L., Yang, J. Z., Wang, J., Qin, Y., Zhang, G. L., Ren, D. Q., Cui, C. L., and Guo, X. G., Anatomical information for intercostobrachial nerve preservation in axillary lymph node dissection for breast cancer, vol. 13, pp. 9315-9323, 2014.

This study aimed to provide additional anatomical information for axillary lymph node dissection (ALND) through in vivo anatomy studies of intercostobrachial nerve (ICBN) preservation in order to provide theoretical and practical experience for clinicians. A total of 156 patients with breast cancer underwent ALND at the Department of Gynecology of Baotou Tumor Hospital between June 2009 and March 2010.

Analysis of signaling pathways in recurrent breast cancer

J. Z. Wu, Yang, T. J., Lu, P., and Ma, W., Analysis of signaling pathways in recurrent breast cancer, vol. 13, pp. 10097-10104, 2014.

Breast cancer remains the second largest cause of death in women from cancer. By analyzing gene expression profiles in samples from breast cancer patients, 844 differentially expressed genes (DEGs) were identified in breast cancer metastasis. The 10 most significant signaling pathways identified through enrichment analysis contained DEGs were involved in oxidative phosphorylation, DNA replication, extracellular matrix-receptor interactions and others.

Sodium valproate inhibits MDA-MB-231 breast cancer cell migration by upregulating NM23H1 expression

G. - F. Li, Qian, T. - L., Li, G. - S., Yang, C. - X., Qin, M., Huang, J., Sun, M., and Han, Y. - Q., Sodium valproate inhibits MDA-MB-231 breast cancer cell migration by upregulating NM23H1 expression, vol. 11, pp. 77-86, 2012.

Breast cancer is a common cancer in women, with a highly variable course, from inoffensive to lethal. To find a more effective strategy for its treatment, sodium valproate has been tested as an anti-cancer drug; it is the only clinically available histone deacetylase inhibitor. However, data about the effects of sodium valproate on breast cancer are insufficient in both animals and humans; studies have yielded conflicting conclusions. In particular, little is known about the association between expression of the metastasis suppressor Nm23H1 gene and breast cancer.

Association of DNMT1 and DNMT3B polymorphisms with breast cancer risk in Han Chinese women from South China

M. - Y. Sun, Yang, X. - X., Xu, W. - W., Yao, G. - Y., Pan, H. - Z., and Li, M., Association of DNMT1 and DNMT3B polymorphisms with breast cancer risk in Han Chinese women from South China, vol. 11, pp. 4330-4341, 2012.

Patterns of DNA methylation are established and maintained by a family of DNA methyltransferases (DNMTs). Aberrant promoter DNA methylation of tumor suppressor genes is found in breast cancer. Association studies between DNMT gene polymorphisms and breast cancer in various populations have reported inconsistent results. This study assessed the associations of single nucleotide polymorphisms (SNPs) in DNMT1, DNMT3A, DNMT3B, DNMT3L, and DNMT2 with breast cancer among Han Chinese women from South China.

Association of MHC class-III gene polymorphisms with ER-positive breast cancer in Chinese Han population

Q. Pan, Ning, Y., Chen, L. Z., Zhang, S., Liu, Z. Z., Yang, X. X., Wei, W., Wei, H., Li, Q. G., Yue, H. N., and Wang, J. X., Association of MHC class-III gene polymorphisms with ER-positive breast cancer in Chinese Han population, vol. 11, pp. 4299-4306, 2012.

Polymorphisms of the major histocompatibility complex (MHC) have been linked to many diseases, especially autoimmune disorders. Previous studies have shown that genetic variants in MHC class III are associated with breast cancer. To determine if there is an association between MHC class III and breast cancer risk in the Chinese Han population, we carried out a hospital-based case-control study in Guangdong and Jiangsu Provinces, including 216 histologically confirmed breast cancer patients and 216 healthy controls.

Plasma human mammaglobin mRNA associated with poor outcome in patients with breast cancer

G. - W. Lee, Kim, J. - Y., Koh, E. - H., Kang, D., Choi, D. S., Maeng, K. - Y., and Lee, J. - S., Plasma human mammaglobin mRNA associated with poor outcome in patients with breast cancer, vol. 11, pp. 4034-4042, 2012.

Different treatment outcomes and prognoses in patients with breast cancer can be observed with similar clinical predictors; this is because the biology of breast cancer is complex and heterogenous, involving multiple unknown contributing factors. We looked for plasma human mammaglobin (hMAM) mRNA by RT-PCR in 82 Korean patients with breast cancer to determine if there is an association between the presence of plasma hMAM mRNA in these patients and known prognostic factors.

Ketamine used as an acesodyne in human breast cancer therapy causes an undesirable side effect, upregulating anti-apoptosis protein Bcl-2 expression

H. He, Chen, J., Xie, W. P., Cao, S., Hu, H. Y., Yang, L. Q., and Gong, B., Ketamine used as an acesodyne in human breast cancer therapy causes an undesirable side effect, upregulating anti-apoptosis protein Bcl-2 expression, vol. 12, pp. 1907-1915, 2013.

Ketamine is a dissociative anesthetic agent that has been widely used in surgery and for relieving pain in chronic cancer patients. We applied ketamine to breast cancer cell line MDA-MB-231 to detect the effect of treatment and molecular mechanisms involved. We found that ketamine can upregulate the level of anti-apoptosis protein Bcl-2, which promotes breast cancer cell invasion and proliferation. Knockdown of Bcl-2 could inhibit the increase of Bcl-2 and reduce the invasion and proliferation caused by ketamine in human breast cancer cells.

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