Low productivity of ribonucleotide reductase in Saccharomyces cerevisiae increases sensitivity to stannous chloride
“Low productivity of ribonucleotide reductase in Saccharomyces cerevisiae increases sensitivity to stannous chloride”, vol. 7, pp. 1-6, 2008.
, Ribonucleotide reductase (RNR) of the yeast Saccharomyces cerevisiae is a tetrameric protein complex, consisting of two large and two small subunits. The small subunits Y2 and Y4 form a heterodimer and are encoded by yeast genes RNR2 and RNR4, respectively. Loss of Y4 in yeast mutant rnr4Δ can be compensated for by up-regulated expression of Y2, and the formation of a small subunit Y2Y2 homodimer that allows for a partially functional RNR.