C-Jun N-terminal kinase

Paclitaxel induces apoptosis in leukemia cells through a JNK activation-dependent pathway

Z. G. Peng, Liu, D. C., Yao, Y. B., Feng, X. L., Huang, X., Tang, Y. L., Yang, J., Wang, X. X., Peng, Z. G., Liu, D. C., Yao, Y. B., Feng, X. L., Huang, X., Tang, Y. L., Yang, J., and Wang, X. X., Paclitaxel induces apoptosis in leukemia cells through a JNK activation-dependent pathway, vol. 15, p. -, 2016.

Paclitaxel (PTX) is a mitotic inhibitor widely used in chemotherapy for many types of cancers, including solid tumors and hematological malignancies. However, the molecular basis of the anti-proliferation activity of PTX is not fully understood. In this paper, we focused on the role of c-Jun N-terminal kinase (JNK) pathways in PTX-induced apoptosis and proliferation inhibition.

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