C4A gene

Increased expression of a novel splice variant of the complement component 4 (C4A) gene in mastitis-infected dairy cattle

Y. Yang, Huang, J. M., Ju, Z. H., Li, Q. L., Zhou, L., Li, R. L., Li, J. B., Shi, F. X., Zhong, J. F., and Wang, C. F., Increased expression of a novel splice variant of the complement component 4 (C4A) gene in mastitis-infected dairy cattle, vol. 11, pp. 2909-2916, 2012.

The complement system helps in the direct lysis of invading pathogens and modulates phagocytic, humoral and cellular immune responses. Complement 4 is a critical component in complement activity and protection against many bacterial pathogens because it is essential to classical and lectin activation pathways. We used reverse transcription and PCR to investigate alternative splicing and expression of the complement component 4 (C4A) gene in Chinese Holstein cattle. The PCR products were cloned and sequenced.

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